TY - JOUR AB - RATIONALE: Population-based studies have found evidence of a relationship between occupational exposures and Chronic Obstructive Pulmonary Disease (COPD), but these studies are limited by the use of prebronchodilator spirometry. Establishing this link using postbronchodilator is critical, because occupational exposures are a modifiable risk factor for COPD. OBJECTIVES: To investigate the associations between occupational exposures and fixed airflow obstruction using postbronchodilator spirometry. METHODS: One thousand three hundred and thirty-five participants were included from 2002 to 2008 follow-up of the Tasmanian Longitudinal Health Study (TAHS). Spirometry was performed and lifetime work history calendars were used to collect occupational history. ALOHA plus Job Exposure Matrix was used to assign occupational exposure, and defined as ever exposed and cumulative exposure unit (EU)-years. Fixed airflow obstruction was defined by postbronchodilator FEV(1)/FVC <0.7 and the lower limit of normal (LLN). Multinomial logistic regressions were used to investigate potential associations while controlling for possible confounders. RESULTS: Ever exposure to biological dust (relative risk (RR)=1.58, 95% CI 1.01 to 2.48), pesticides (RR=1.74,95% CI 1.00 to 3.07) and herbicides (RR=2.09,95% CI 1.18 to 3.70) were associated with fixed airflow obstruction. Cumulative EU-years to all pesticides (RR=1.11,95% CI 1.00 to 1.25) and herbicides (RR=1.15,95% CI 1.00 to 1.32) were also associated with fixed airflow obstruction. In addition, all pesticides exposure was consistently associated with chronic bronchitis and symptoms that are consistent with airflow obstruction. Ever exposure to mineral dust, gases/fumes and vapours, gases, dust or fumes were only associated with fixed airflow obstruction in non-asthmatics only. CONCLUSIONS: Pesticides and herbicides exposures were associated with fixed airflow obstruction and chronic bronchitis. Biological dust exposure was also associated with fixed airflow obstruction in non-asthmatics. Minimising occupational exposure to these agents may help to reduce the burden of COPD. AD - Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. Murdoch Childrens Research Institute, Melbourne, Victoria, Australia. Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Graduate Entry Medical School, University of Limerick, Limerick, Ireland. Department of Respiratory and Sleep Medicine, Austin Hospital, Melbourne, Victoria, Australia. Department of Medicine, University of Queensland, Brisbane, Queensland, Australia. School of Medicine, University of Tasmania, Hobart, Tasmania, Australia. Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia. Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Allergy Immunology and Respiratory Medicine, The Alfred Hospital, Melbourne, Victoria, Australia. Gold Coast University Hospital, Southport, Queensland, Australia. Bond University, Robina, Queensland, Australia. Environmental Epidemiology Division, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands. AN - 28687678 AU - Alif, S. M. AU - Dharmage, S. C. AU - Benke, G. AU - Dennekamp, M. AU - Burgess, J. A. AU - Perret, J. L. AU - Lodge, C. J. AU - Morrison, S. AU - Johns, D. P. AU - Giles, G. G. AU - Gurrin, L. C. AU - Thomas, P. S. AU - Hopper, J. L. AU - Wood-Baker, R. AU - Thompson, B. R. AU - Feather, I. H. AU - Vermeulen, R. AU - Kromhout, H. AU - Walters, E. H. AU - Abramson, M. J. AU - Matheson, M. C. C1 - Competing interests: None declared. C2 - Alif 2017 DA - Nov DB - Medline DO - 10.1136/thoraxjnl-2016-209665 DP - NLM ET - 20170707 IS - 11 KW - Adult Female Follow-Up Studies Forced Expiratory Volume Humans Longitudinal Studies Male Middle Aged Occupational Exposure/*adverse effects Pesticides/*toxicity Prevalence Pulmonary Disease, Chronic Obstructive/*chemically induced/epidemiology/physiopathology Risk Factors Smoking/adverse effects Spirometry Surveys and Questionnaires Tasmania/epidemiology Aloha jem Airflow obstruction Chronic obstructive pulmonary disease Job exposure matrix Occupational exposure Pesticide N1 - Alif, Sheikh M Dharmage, Shyamali C Benke, Geza Dennekamp, Martine Burgess, John A Perret, Jennifer L Lodge, Caroline J Morrison, Stephen Johns, David Peter Giles, Graham G Gurrin, Lyle C Thomas, Paul S Hopper, John Llewelyn Wood-Baker, Richard Thompson, Bruce R Feather, Iain H Vermeulen, Roel Kromhout, Hans Walters, E Haydn Abramson, Michael J Matheson, Melanie Claire eng Research Support, Non-U.S. Gov't England 2017/07/09 Thorax. 2017 Nov;72(11):990-997. doi: 10.1136/thoraxjnl-2016-209665. Epub 2017 Jul 7. PY - 2017 SN - 1468-3296 (Electronic) 0040-6376 (Linking) SP - 990-997 ST - Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age T2 - Thorax TI - Occupational exposure to pesticides are associated with fixed airflow obstruction in middle-age UR - https://www.ncbi.nlm.nih.gov/pubmed/28687678 VL - 72 ID - 68 ER - TY - JOUR AB - PURPOSE: To study respiratory effects of exposure to soft paper dust exposure, a relationship that is rarely studied. METHODS: Soft tissue paper mill workers at a Swedish paper mill were investigated using a questionnaire and lung function and atopy screening. Spirometry without bronchodilation was performed with a dry wedge spirometer, and forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) were obtained and expressed as percent predicted. Exposure to soft paper dust was assessed from historical stationary and personal measurements of total dust, in addition to historical information about the work, department, and production. The impact of high exposure to soft paper dust (> 5 mg/m(3)) vs. lower exposure 10% [odds ratio (OR) 5.98, 4.98, and 3.87, respectively). They also had higher percentages of neutrophils and lymphocytes in the induced sputum. Conclusion Laminators should undergo regular check-ups of respiratory symptoms and lung function. Further toxicologic studies are warranted to identify the specific causal agent in the FRP lamination process. AD - Department of Environmental and Occupational Medicine, College of Medicine, National Taiwan University and National Taiwan University Hospital, Rm 339, 17 Syujhou Road, Taipei 100, Taiwan. AN - 32940339 AU - Chen, C. H. AU - Tsai, P. J. AU - Wang, Y. F. AU - Pan, C. H. AU - Hung, P. C. AU - Ho, J. J. AU - Perng, D. W. AU - Nemery, B. AU - Guo, Y. L. C1 - The authors declare no conflicts of interest. C2 - PMC7801144 DA - Jan 1 DB - Medline DO - 10.5271/sjweh.3924 DP - NLM ET - 20200917 IS - 1 KW - *Construction Industry Forced Expiratory Volume Glass Humans Plastics Vital Capacity N1 - Chen, Chi-Hsien Tsai, Perng-Jy Wang, Ya-Fen Pan, Chih-Hong Hung, Po-Chen Ho, Jiune-Jye Perng, Diahn-Warng Nemery, Benoit Guo, Yue Leon eng Research Support, Non-U.S. Gov't Finland 2020/09/18 Scand J Work Environ Health. 2021 Jan 1;47(1):62-69. doi: 10.5271/sjweh.3924. Epub 2020 Sep 17. PY - 2021 SN - 1795-990X (Electronic) 0355-3140 (Print) 0355-3140 (Linking) SP - 62-69 ST - Respiratory health effects of the fiberglass-reinforced plastic lamination process in the yacht-building industry T2 - Scand J Work Environ Health TI - Respiratory health effects of the fiberglass-reinforced plastic lamination process in the yacht-building industry UR - https://www.ncbi.nlm.nih.gov/pubmed/32940339 VL - 47 ID - 194 ER - TY - JOUR AB - SETTING: The prevalence of airflow obstruction (AO) in the Caribbean population is unknown.OBJECTIVE: To measure the prevalence of and risk factors for AO (post-bronchodilator ratio of forced expiratory volume in 1 sec to forced vital capacity of <0.7) in the Trinidad and Tobago general population using the Burden of Obstructive Lung Disease methodology.DESIGN: National cross-sectional, stratified, cluster sampling of adults aged >/=40 years.RESULTS: AO prevalence was 9.5% among 1104 participants, most of whom were unaware of this. Compared to those aged 40-49 years, the adjusted odds ratio of AO by age group was 2.73 (60-69 years) and 3.30 (>/=70 years). Risk factors for AO were unemployment (OR 4.31), being retired (OR 2.17), smoking >/=20 pack-years (OR 1.88) and exposure to dusty jobs for more than 1 year (OR 2.06). Related symptoms were history of wheezing, unscheduled visits to the doctor or admission to hospital for breathing problems and in subjects with at least one respiratory symptom (OR 1.90), at least one risk factor (OR 2.81), either symptoms or risk factors (OR 3.71) and both symptoms and risk factors (OR 5.78) (P < 0.05 in all cases).CONCLUSION: AO prevalence in the general population of Trinidad and Tobago aged >/=40 years was 9.5%, almost all of which was undiagnosed. AO was associated with smoking, age >59 years, lack of employment and working in a dusty job. AD - South-West Regional Health Authority, San Fernando, Trinidad and Tobago. Faculty of Medical Sciences, The University of the West Indies, St Augustine Campus, Trinidad and Tobago. National Heart and Lung Institute, Imperial College, London, UK. AN - 32398201 AU - Conyette, L. AU - Lutchmansingh, F. AU - Sakhamuri, S. AU - Simeon, D. AU - Ivey, M. A. AU - Burney, P. AU - Seemungal, T. C1 - 116 C2 - Conyette 2020 DA - May 1 DB - Medline DO - 10.5588/ijtld.19.0578 DP - NLM IS - 5 KW - Adolescent Adult Aged Caribbean Region Child Child, Preschool Cross-Sectional Studies Forced Expiratory Volume Humans Middle Aged Prevalence *Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology Risk Factors Spirometry Vital Capacity Young Adult N1 - Conyette, L Lutchmansingh, F Sakhamuri, S Simeon, D Ivey, M A Burney, P Seemungal, T eng Research Support, Non-U.S. Gov't France 2020/05/14 Int J Tuberc Lung Dis. 2020 May 1;24(5):512-519. doi: 10.5588/ijtld.19.0578. PY - 2020 SN - 1815-7920 (Electronic) 1027-3719 (Linking) SP - 512-519 ST - Prevalence and risk factors of airflow obstruction in a Caribbean population T2 - Int J Tuberc Lung Dis TI - Prevalence and risk factors of airflow obstruction in a Caribbean population UR - https://www.ncbi.nlm.nih.gov/pubmed/32398201 VL - 24 ID - 149 ER - TY - JOUR AB - This case-control study aimed to investigate whether the levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes were associated with the risk of chronic obstructive pulmonary disease (COPD) among coal workers. A total of 76 COPD cases and 48 age-matched healthy controls from a group of coal workers were included. The case group consisted of 35 COPD patients whose condition was complicated with coal workers' pneumoconiosis (CWP) and 41 COPD patients without CWP. Heat shock proteins (Hsps) in plasma and lymphocytes were detected by ELISA and flow cytometry, respectively. Multiple logistic regression models were applied to estimate the association between Hsp levels and COPD risk. Our results showed that plasma Hsp70 and lymphocyte Hsp27 levels were significantly higher and plasma Hsp27 levels were significantly lower in COPD cases than in controls (p < 0.01). No significant differences in lymphocyte Hsp70 levels were found between COPD cases and the matched subjects. Higher plasma Hsp70 levels (odds ratio (OR) = 13.8, 95 % confidence interval (CI) = 5.7-33.5) and lower plasma Hsp27 levels (OR = 4.6, 95 % CI = 2.0-10.5) were significantly associated with an increased risk of COPD after adjusting for confounders. Higher lymphocyte Hsp27 levels were only associated with an increased risk of COPD with CWP (OR = 6.6, 95 % CI = 2.0-22.1) but not with an increased risk of COPD without CWP (OR = 3.0, 95 % CI = 0.9-8.9). Additionally, there were strong joint effects of different Hsps on COPD risk. These results showed that higher levels of plasma Hsp70 and lower levels of plasma Hsp27 might be associated with an increased risk of COPD among coal workers. They may have the potential to serve as monitoring markers for COPD in coal workers. AD - Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. AN - 25620081 AU - Cui, X. AU - Xing, J. AU - Liu, Y. AU - Zhou, Y. AU - Luo, X. AU - Zhang, Z. AU - Han, W. AU - Wu, T. AU - Chen, W. C1 - 8687 C2 - PMC4406932 DA - May DB - Medline DO - 10.1007/s12192-015-0572-5 DP - NLM ET - 20150127 IS - 3 KW - Aged Anthracosis/*blood/immunology Biomarkers/blood Case-Control Studies *Coal *Coal Mining HSP27 Heat-Shock Proteins/*blood HSP70 Heat-Shock Proteins/*blood Heat-Shock Proteins Humans Lymphocytes/*metabolism Male Middle Aged Miners Molecular Chaperones *Occupational Exposure Pneumoconiosis/blood/immunology Pulmonary Disease, Chronic Obstructive/*blood/immunology Risk Factors N1 - Cui, Xiuqing Xing, Jingcai Liu, Yuewei Zhou, Yun Luo, Xin Zhang, Zhihong Han, Wenhui Wu, Tangchun Chen, Weihong eng Research Support, Non-U.S. Gov't Netherlands 2015/01/27 Cell Stress Chaperones. 2015 May;20(3):473-81. doi: 10.1007/s12192-015-0572-5. Epub 2015 Jan 27. PY - 2015 SN - 1466-1268 (Electronic) 1355-8145 (Print) 1355-8145 (Linking) SP - 473-81 ST - COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study T2 - Cell Stress Chaperones TI - COPD and levels of Hsp70 (HSPA1A) and Hsp27 (HSPB1) in plasma and lymphocytes among coal workers: a case-control study UR - https://www.ncbi.nlm.nih.gov/pubmed/25620081 VL - 20 ID - 88 ER - TY - JOUR AB - OBJECTIVE: To assess the contribution of workplace exposures to chronic obstructive pulmonary disease (COPD) risk in a community with a heavy burden of past industrial employment. METHODS: A random population sample of Sheffield, U.K. residents aged over 55 years (n=4000), enriched with a hospital-based supplemental sample (n=209), was approached for study. A comprehensive self-completed questionnaire elicited physician-made diagnoses, current symptoms, and past workplace exposures. The latter were defined in three ways: self-reported exposure to vapours, gases, dusts and fumes (VGDF); response to a specific exposure checklist; and through a job exposure matrix (JEM) assigning exposure risk likelihood based on job history independent of respondent-reported exposure. A subset of the study group underwent lung function testing. Population attributable risk fractions (PAR%), adjusted for age, sex and smoking, were calculated for association between workplace exposure and COPD. RESULTS: 2001 (50%) questionnaires were returned from the general population sample and 60 (29%) by the hospital supplement. Among 1754 with complete occupational data, any past occupational exposure to VGDF carried an adjusted excess risk for report of a physician's diagnosis of COPD, emphysema, or chronic bronchitis (ORs 3.9; 95% CI 2.7 to 5.8), with a corresponding PAR% value of 58.7% (95% CI 45.6% to 68.7%). The PAR% estimate based on JEM exposure was 31%. From within the subgroup of 571 that underwent lung function testing, VGDF exposure was associated with a PAR% of 20.0% (95% CI -7.2 to 40.3%) for Global initiative for chronic obstructive lung disease (GOLD) 1 (or greater) level of COPD. CONCLUSION: This heavy industrial community-based population study has confirmed significant associations between reported COPD and both generic VGDF and JEM-defined exposures. This study supports the predominantly international evidence-based notion that workplace conditions are important when considering the current and future respiratory health of the workforce. AD - Centre for Workplace Health, Health and Safety Laboratory, Buxton SK17 9JN, UK. anthony.darby@nhs.net AN - 22744883 AU - Darby, A. C. AU - Waterhouse, J. C. AU - Stevens, V. AU - Billings, C. G. AU - Billings, C. G. AU - Burton, C. M. AU - Young, C. AU - Wight, J. AU - Blanc, P. D. AU - Fishwick, D. C1 - 8690 C2 - Darby 2012 DA - Oct DB - Medline DO - 10.1136/thoraxjnl-2011-200543 DP - NLM ET - 20120628 IS - 10 KW - Aged Air Pollutants, Occupational/*adverse effects England/epidemiology Female Humans Industry Logistic Models Male Middle Aged Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*epidemiology Respiratory Function Tests Risk Factors Smoking/epidemiology Surveys and Questionnaires Workplace N1 - Darby, Anthony C Waterhouse, Judith C Stevens, Vivien Billings, Clare G Billings, Catherine G Burton, Clare M Young, Charlotte Wight, Jeremy Blanc, Paul D Fishwick, David eng England 2012/06/30 Thorax. 2012 Oct;67(10):901-7. doi: 10.1136/thoraxjnl-2011-200543. Epub 2012 Jun 28. PY - 2012 SN - 1468-3296 (Electronic) 0040-6376 (Linking) SP - 901-7 ST - Chronic obstructive pulmonary disease among residents of an historically industrialised area T2 - Thorax TI - Chronic obstructive pulmonary disease among residents of an historically industrialised area UR - https://www.ncbi.nlm.nih.gov/pubmed/22744883 VL - 67 ID - 89 ER - TY - JOUR AB - BACKGROUND AND AIM: Occupational exposures are important, preventable causes of COPD. We previously found an increased risk of COPD among six occupations by analysing lifetime job histories and lung function data in the population-based UK Biobank cohort. We aimed to build on these findings and elucidate the underlying potential causal agents to focus preventive strategies. METHODS: We applied the ALOHA+job exposure matrix (JEM) based on the International Standard Classification of Occupations V.1988 codes, where exposure to 12 selected agents was rated as 0 (no exposure), 1 (low) or 2 (high). COPD was spirometrically defined as FEV(1)/FVC less than the lower limit of normal. We calculated semiquantitative cumulative exposure estimates for each agent by multiplying the duration of exposure and squared intensity. Prevalence ratio (PR) and 95% CI for COPD were estimated using robust Poisson regression adjusted for centre, sex, age, smoking and coexposure to JEM agents. Only associations confirmed among never-smokers and never-asthmatics were considered reliable. RESULTS: Out of 116 375 participants with complete job histories, 94 514 had acceptable/repeatable spirometry and smoking data and were included in the analysis. Pesticide exposure showed increased risk of COPD for ever exposure (PR=1.13, 95% CI 1.01 to 1.28) and high cumulative exposure (PR=1.32, 95% CI 1.12 to 1.56), with positive exposure-response trends (p trend=0.004), which were confirmed among never-smokers (p trend=0.005) and never-asthmatics (p trend=0.001). CONCLUSION: In a large population-based study, occupational exposure to pesticides was associated with risk of COPD. Focused preventive strategies for workers exposed to pesticides can prevent the associated COPD burden. AD - National Heart and Lung Institute, Imperial College London, London, UK s.de-matteis@imperial.ac.uk. Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy. National Heart and Lung Institute, Imperial College London, London, UK. MRC Centre for Environment and Health, Imperial College, London, UK. Science Division, Health and Safety Executive, Harpur Hill Buxton, UK. Epidemiology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Institute for Risk Assessment Sciences, University of Utrecht, Utrecht, The Netherlands. School of Health Sciences, University of Manchester, Manchester, UK. Occupational and Environmental Medicine, University of Birmingham, Birmingham, UK. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK. AN - 35082144 AU - De Matteis, S. AU - Jarvis, D. AU - Darnton, L. AU - Consonni, D. AU - Kromhout, H. AU - Hutchings, S. AU - Sadhra, S. S. AU - Fishwick, D. AU - Vermeulen, R. AU - Rushton, L. AU - Cullinan, P. C1 - Competing interests: None declared. C2 - DeMatteis 2022 DA - Oct DB - Medline DO - 10.1136/thoraxjnl-2020-216523 DP - NLM ET - 20220126 IS - 10 KW - Humans Biological Specimen Banks Risk Factors *Pulmonary Disease, Chronic Obstructive/epidemiology/etiology *Occupational Exposure/adverse effects *Asthma/complications *Pesticides United Kingdom/epidemiology *Occupational Diseases/etiology/complications COPD epidemiology occupational lung disease N1 - De Matteis, Sara Jarvis, Debbie Darnton, Lucy Consonni, Dario Kromhout, Hans Hutchings, Sally Sadhra, Steven S Fishwick, David Vermeulen, Roel Rushton, Lesley Cullinan, Paul eng MC_PC_17228/MRC_/Medical Research Council/United Kingdom MC_QA137853/MRC_/Medical Research Council/United Kingdom MR/S019669/1/MRC_/Medical Research Council/United Kingdom Research Support, Non-U.S. Gov't England 2022/01/28 Thorax. 2022 Oct;77(10):997-1005. doi: 10.1136/thoraxjnl-2020-216523. Epub 2022 Jan 26. PY - 2022 SN - 1468-3296 (Electronic) 0040-6376 (Linking) SP - 997-1005 ST - Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort T2 - Thorax TI - Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort UR - https://www.ncbi.nlm.nih.gov/pubmed/35082144 VL - 77 ID - 82 ER - TY - JOUR AB - BACKGROUND: While smoking is the major cause of chronic obstructive pulmonary disease (COPD), occupational exposures to vapors, gases, dusts, and fumes (VGDF) increase COPD risk. This case-control study estimated the risk of COPD attributable to occupational exposures among construction workers. METHODS: The study population included 834 cases and 1243 controls participating in a national medical screening program for older construction workers between 1997 and 2013. Qualitative exposure indices were developed based on lifetime work and exposure histories. RESULTS: Approximately 18% (95% CI = 2-24%) of COPD risk can be attributed to construction-related exposures, which are additive to the risk contributed by smoking. A measure of all VGDF exposures combined was a strong predictor of COPD risk. CONCLUSIONS: Construction workers are at increased risk of COPD as a result of broad and complex effects of many exposures acting independently or interactively. Control methods should be implemented to prevent worker exposures, and smoking cessation should be promoted. AD - Division of Occupational and Environmental Medicine, Duke University Medical Center, Durham, North Carolina. The Center for Construction Research and Training, Silver Spring, Maryland. Stoneturn Consultants, Seattle, Washington. Zenith American Solutions, Seattle, Washington. AN - 26123003 AU - Dement, J. AU - Welch, L. AU - Ringen, K. AU - Quinn, P. AU - Chen, A. AU - Haas, S. C1 - 285 C2 - PMC5034836 DA - Oct DB - Medline DO - 10.1002/ajim.22495 DP - NLM ET - 20150629 IS - 10 KW - Adult Aged Aged, 80 and over Air Pollutants, Occupational/*adverse effects/analysis Case-Control Studies *Construction Industry Female Humans Male Middle Aged Occupational Diseases/epidemiology/*etiology Occupational Exposure/*adverse effects/analysis Pulmonary Disease, Chronic Obstructive/epidemiology/*etiology Risk Factors United States/epidemiology Copd attributable risk construction workers dusts fumes gasses occupational risks smoking vapors N1 - Dement, John Welch, Laura Ringen, Knut Quinn, Patricia Chen, Anna Haas, Scott eng R01 OH009943/OH/NIOSH CDC HHS/ 5R01OH009943/OH/NIOSH CDC HHS/ Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. 2015/07/01 Am J Ind Med. 2015 Oct;58(10):1083-97. doi: 10.1002/ajim.22495. Epub 2015 Jun 29. PY - 2015 SN - 1097-0274 (Electronic) 0271-3586 (Print) 0271-3586 (Linking) SP - 1083-97 ST - A case-control study of airways obstruction among construction workers T2 - Am J Ind Med TI - A case-control study of airways obstruction among construction workers UR - https://www.ncbi.nlm.nih.gov/pubmed/26123003 VL - 58 ID - 67 ER - TY - JOUR AB - INTRODUCTION: The contribution of occupational exposure to the risk of chronic obstructive pulmonary disease COPD in population-based studies is of interest. We compared the performance of self-reported exposure to a newly developed JEM in exposure-response evaluation. METHODS: We used cross-sectional data from Multi-Ethnic Study of Atherosclerosis (MESA), a population-based sample of 45-84 year olds free of clinical cardiovascular disease at baseline. MESA ascertained the most recent job and employment, and the MESA Lung Study measured spirometry, and occupational exposures for 3686 participants. Associations between health outcomes (spirometry defined airflow limitation and Medical Research Council-defined chronic bronchitis) and occupational exposure [self-reported occupational exposure to vapor-gas, dust, or fumes (VGDF), severity of exposure, and a job-exposure matrix (JEM)-derived score] were evaluated using logistic regression models adjusted for non-occupational risk factors. RESULTS: The prevalence of airflow limitation was associated with self-reported exposure to vapor-gas (OR 2.6, 95%CI 1.1-2.3), severity of VGDF exposure (P-trend < 0.01), and JEM dust exposure (OR 2.4, 95%CI 1.1-5.0), and with organic dust exposure in females; these associations were generally of greater magnitude among never smokers. The prevalence of chronic bronchitis and wheeze was associated with exposure to VGDF. The association between airflow limitation and the combined effect of smoking and VGDF exposure showed an increasing trend. Self-reported vapor-gas, dust, fumes, years and severity of exposure were associated with increased prevalence of chronic bronchitis and wheeze (P < 0.001). CONCLUSIONS: Airflow limitation was associated with self-reported VGDF exposure, its severity, and JEM-ascertained dust exposure in smokers and never-smokers in this multiethnic study. AD - 1National Institute for Occupational Safety and Health (preferred mailing address)Division of Respiratory Disease Studies, Surveillance Branch 1095 Willowdale Road Morgantown , West Virginia, 26505 USA and West Virginia University School of Public Health PO Box 9190 Morgantown, WV, 26506 USA , Email: bdoney@cdc.gov , Fax: (304) 285-6111. AN - 24568208 AU - Doney, B. AU - Hnizdo, E. AU - Graziani, M. AU - Kullman, G. AU - Burchfiel, C. AU - Baron, S. AU - Fujishiro, K. AU - Enright, P. AU - Hankinson, J. L. AU - Stukovsky, K. H. AU - Martin, C. J. AU - Donohue, K. M. AU - Barr, R. G. C1 - 8450 C2 - PMC4096066 DA - Aug DB - Medline DO - 10.3109/15412555.2013.813448 DP - NLM ET - 20140225 IS - 4 KW - Aged Aged, 80 and over Atherosclerosis/epidemiology Bronchitis, Chronic/*epidemiology Cross-Sectional Studies Dust/*analysis Ethnicity Female Forced Expiratory Volume Gases/*analysis/toxicity Humans Male Middle Aged Occupational Exposure/adverse effects/*analysis Phenotype Prevalence Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology Respiratory Sounds Risk Factors *Self Report Smoking Spirometry United States/epidemiology Vital Capacity airflow obstruction dust fumes gas job exposure matrix N1 - Doney, Brent Hnizdo, Eva Graziani, Monica Kullman, Greg Burchfiel, Cecil Baron, Sherry Fujishiro, Kaori Enright, Paul Hankinson, John L Stukovsky, Karen Hinckley Martin, Christopher J Donohue, Kathleen M Barr, R Graham eng N01HC95169/HL/NHLBI NIH HHS/ R01 HL077612/HL/NHLBI NIH HHS/ N01-HC-95165/HC/NHLBI NIH HHS/ R01 HL093081/HL/NHLBI NIH HHS/ N01HC95159/HL/NHLBI NIH HHS/ FY08 CRN SLB8/PHS HHS/ R01 HL075476/HL/NHLBI NIH HHS/ HL075476/HL/NHLBI NIH HHS/ HL077612/HL/NHLBI NIH HHS/ P30 ES009089/ES/NIEHS NIH HHS/ N01-HC-95159/HC/NHLBI NIH HHS/ T32 ES015459/ES/NIEHS NIH HHS/ N01-HC-95169/HC/NHLBI NIH HHS/ N01HC95165/HL/NHLBI NIH HHS/ Comparative Study Research Support, N.I.H., Extramural Research Support, U.S. Gov't, P.H.S. England 2014/02/27 COPD. 2014 Aug;11(4):368-80. doi: 10.3109/15412555.2013.813448. Epub 2014 Feb 25. PY - 2014 SN - 1541-2563 (Electronic) 1541-2555 (Print) 1541-2563 (Linking) SP - 368-80 ST - Occupational risk factors for COPD phenotypes in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study T2 - COPD TI - Occupational risk factors for COPD phenotypes in the Multi-Ethnic Study of Atherosclerosis (MESA) Lung Study UR - https://www.ncbi.nlm.nih.gov/pubmed/24568208 VL - 11 ID - 112 ER - TY - JOUR AB - INTRODUCTION: This study examined the association of spirometry-defined airflow obstruction and self-reported COPD defined as self-reported doctor diagnosed chronic bronchitis or emphysema, with occupational exposure among ever-employed US adults. METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2007-2008 to 2011-2012, a nationally representative study of the non-institutionalized civilian US population. Reported current and/or longest held job were used to create prevalence estimates and prevalence odds ratios (PORs) (adjusted for age, gender, race, and smoking status) for airflow obstruction and self-reported COPD by occupational exposure, determined using both NHANES participants' self-reported exposures and eight categories of COPD job exposure matrix (JEM) assigned exposures. RESULTS: Significant PORs for airflow obstruction and self-reported COPD respectively were observed with self-reported exposure for >/=20 years to mineral dust (POR = 1.44; 95% confidence interval (CI) 1.13-1.85; POR = 1.69; 95% CI 1.17-2.43) and exhaust fumes (POR = 1.65; 95% CI 1.27-2.15; POR = 2.22; 95% CI 1.37-3.58). Airflow obstruction or self-reported COPD were also associated with COPD-JEM assigned high exposure to mineral dust, combined dust, diesel exhaust, vapor-gas, sensitizers, and overall exposure. CONCLUSION: Airflow obstruction and self-reported COPD are associated with both self-reported and JEM-assigned exposures. AD - Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia. Division of Health and Nutrition Examination Surveys, National Center for Health Statistics, Centers for Disease Control and Prevention, Hyattsville, Maryland. AN - 30775792 AU - Doney, B. AU - Kurth, L. AU - Halldin, C. AU - Hale, J. AU - Frenk, S. M. C1 - The authors report no conflicts of interest. C2 - PMC6661888 DA - May DB - Medline DO - 10.1002/ajim.22958 DP - NLM ET - 20190218 IS - 5 KW - Adult Aged Female Humans Male Middle Aged Nutrition Surveys Occupational Diseases/*chemically induced/*epidemiology Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*chemically induced/*epidemiology Risk Factors Self Report Smoking/epidemiology Spirometry United States/epidemiology Young Adult (5-10): airflow obstruction Cdc Copd Nhanes job exposure matrix occupational exposure prevalence N1 - Doney, Brent Kurth, Laura Halldin, Cara Hale, Janet Frenk, Steven M eng CC999999/ImCDC/Intramural CDC HHS/ Comparative Study Research Support, U.S. Gov't, P.H.S. 2019/02/19 Am J Ind Med. 2019 May;62(5):393-403. doi: 10.1002/ajim.22958. Epub 2019 Feb 18. PY - 2019 SN - 1097-0274 (Electronic) 0271-3586 (Print) 0271-3586 (Linking) SP - 393-403 ST - Occupational exposure and airflow obstruction and self-reported COPD among ever-employed US adults using a COPD-job exposure matrix T2 - Am J Ind Med TI - Occupational exposure and airflow obstruction and self-reported COPD among ever-employed US adults using a COPD-job exposure matrix UR - https://www.ncbi.nlm.nih.gov/pubmed/30775792 VL - 62 ID - 70 ER - TY - JOUR AB - IMPORTANCE: Exposure to disinfectants in health care workers has been associated with respiratory health outcomes, including asthma. Despite the biological plausibility of an association between disinfectants (irritant chemicals) and risk of chronic obstructive pulmonary disease (COPD), available data are sparse. OBJECTIVE: To investigate the association between exposure to disinfectants and COPD incidence in a large cohort of US female nurses. DESIGN, SETTING, AND PARTICIPANTS: The Nurses' Health Study II is a US prospective cohort study of 116 429 female registered nurses from 14 US states who were enrolled in 1989 and followed up through questionnaires every 2 years since. The present study included women who were still in a nursing job and had no history of COPD in 2009, and used data from the 2009 through 2015 questionnaires. Clean and complete data used for this analysis were available in July 2018, and analyses were conducted from September 2018 through August 2019. EXPOSURES: Occupational exposure to disinfectants, evaluated by questionnaire and a job-task-exposure matrix (JTEM). MAIN OUTCOMES AND MEASURES: Incident physician-diagnosed COPD evaluated by questionnaire. RESULTS: Among the 73 262 women included in the analyses, mean (SD) age at baseline was 54.7 (4.6) years and 70 311 (96.0%) were white, 1235 (1.7%) black, and 1716 (2.3%) other; and 1345 (1.8%) Hispanic, and 71 917 (98.2%) non-Hispanic. Based on 368 145 person-years of follow-up, 582 nurses reported incident physician-diagnosed COPD. Weekly use of disinfectants to clean surfaces only (16 786 [22.9%] of participants exposed) and to clean medical instruments (13 899 [19.0%] exposed) was associated with COPD incidence, with adjusted hazard ratios of 1.38 (95% CI, 1.13-1.68) for cleaning surfaces only and 1.31 (95% CI, 1.07-1.61) for cleaning medical instruments after adjustment for age, smoking (pack-years), race, ethnicity, and body mass index. High-level exposure, evaluated by the JTEM, to several specific disinfectants (ie, glutaraldehyde, bleach, hydrogen peroxide, alcohol, and quaternary ammonium compounds) was significantly associated with COPD incidence, with adjusted hazard ratios ranging from 1.25 (95% CI, 1.04-1.51) to 1.36 (95% CI, 1.13-1.64). Associations were not modified by smoking or asthma status (P for interaction > .15). CONCLUSIONS AND RELEVANCE: These longitudinal results suggest that regular use of chemical disinfectants among nurses may be a risk factor for developing COPD. If future studies confirm these results, exposure-reduction strategies that are compatible with infection control in health care settings should be developed. AD - INSERM U1168, VIMA: Aging and Chronic Diseases, Epidemiological and Public Health Approaches, F-94807, Villejuif, France. University de Versailles St-Quentin-en-Yvelines, UMR-S 1168, F-78180, Montigny le Bretonneux, France. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts. Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. Respiratory Health Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia. AN - 31626315 AU - Dumas, O. AU - Varraso, R. AU - Boggs, K. M. AU - Quinot, C. AU - Zock, J. P. AU - Henneberger, P. K. AU - Speizer, F. E. AU - Le Moual, N. AU - Camargo, C. A., Jr. C1 - Conflict of Interest Disclosures: Drs Dumas, Varraso, Le Moual, and Camargo and Ms Boggs reported receiving grants from the National Institute for Occupational Safety and Health (NIOSH) of the Centers for Disease Control and Prevention (CDC) during the conduct of this study. Dr Zock reported receiving personal fees from Partners HealthCare System, Inc, and being a paid consultant on an NIOSH R01 grant. No other disclosures were reported. C2 - PMC6813668 DA - Oct 2 DB - Medline DO - 10.1001/jamanetworkopen.2019.13563 DP - NLM ET - 20191002 IS - 10 KW - *Disinfectants Female Follow-Up Studies Formaldehyde Glutaral Health Surveys Humans Hydrogen Peroxide Incidence Middle Aged Nurses/*statistics & numerical data Occupational Diseases/*epidemiology Occupational Exposure/*statistics & numerical data Prospective Studies Pulmonary Disease, Chronic Obstructive/*epidemiology Quaternary Ammonium Compounds Sodium Hypochlorite United States/epidemiology N1 - Dumas, Orianne Varraso, Raphaelle Boggs, Krislyn M Quinot, Catherine Zock, Jan-Paul Henneberger, Paul K Speizer, Frank E Le Moual, Nicole Camargo, Carlos A Jr eng R01 OH010359/OH/NIOSH CDC HHS/ UM1 CA176726/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2019/10/19 JAMA Netw Open. 2019 Oct 2;2(10):e1913563. doi: 10.1001/jamanetworkopen.2019.13563. PY - 2019 SN - 2574-3805 (Electronic) 2574-3805 (Linking) SP - e1913563 ST - Association of Occupational Exposure to Disinfectants With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses T2 - JAMA Netw Open TI - Association of Occupational Exposure to Disinfectants With Incidence of Chronic Obstructive Pulmonary Disease Among US Female Nurses UR - https://www.ncbi.nlm.nih.gov/pubmed/31626315 VL - 2 ID - 183 ER - TY - JOUR AB - BACKGROUND: Farmers have an increased risk of respiratory morbidity and mortality. The causal agents have not been fully established. METHODS: In a cross-sectional study of 4,735 Norwegian farmers, we assessed respiratory symptoms and lung function. Atopy was assessed in a subsample (n = 1,213). Personal exposures to dust, fungal spores, actinomycete spores, endotoxins, bacteria, storage mites, (1-->3)-ss-D-glucans, fungal antigens, organic dust, inorganic dust, silica, ammonia, and hydrogen sulfide were measured for 127 randomly selected farms. RESULTS: Compared to crop farmers, livestock farmers were more likely to have chronic bronchitis (odds ratio [OR], 1.9; 95% confidence interval [CI], 1.4 to 2.6) and COPD (OR, 1.4; 95% CI, 1.1 to 1.7). FEV(1) (-41 mL; 95% CI, -75 to -7) was significantly reduced, but FVC (-15 mL; 95% CI, -54 to 24) was not. Exposure to most agents were predictors of respiratory morbidity, except FVC. Ammonia, hydrogen sulfide, and inorganic dust were most strongly associated in multiple regression models adjusted for coexposures, but the effects of specific biological agents could not be assessed in multiple regression models because they were too highly correlated. Farmers with atopy had a significantly lower FEV(1) (OR, -87 mL; 95% CI, -170 to -7), but atopy was not directly associated with chronic bronchitis, COPD, and FVC. However, the effects of farming and specific exposures on COPD were substantially greater in farmers with atopy. CONCLUSIONS: Livestock farmers have an increased risk of chronic bronchitis, COPD, and reduced FEV(1). Ammonia, hydrogen sulfide, inorganic dust, and organic dust may be causally involved, but a role for specific biological agents cannot be excluded. Farmers with atopy appear more susceptible to develop farming-related COPD. AD - National Institute of Occupational Health, Oslo, Norway. Electronic address: wijnand.eduard@stami.no. Centre for Public Health Research, Massey University, Wellington, New Zealands. AN - 19318669 AU - Eduard, W. AU - Pearce, N. AU - Douwes, J. C1 - 371 C2 - Eduard 2009 DA - Sep DB - Medline DO - 10.1378/chest.08-2192 DP - NLM ET - 20090324 IS - 3 KW - Agricultural Workers' Diseases/epidemiology/*etiology/physiopathology Agrochemicals/toxicity Allergens/analysis Animals Animals, Domestic Bronchitis/epidemiology/*etiology/physiopathology Chronic Disease Cross-Sectional Studies Dust Female Humans Male Middle Aged Norway/epidemiology Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/epidemiology/*etiology/physiopathology Regression Analysis Respiratory Function Tests Risk Factors Surveys and Questionnaires N1 - Eduard, Wijnand Pearce, Neil Douwes, Jeroen eng Comparative Study Research Support, Non-U.S. Gov't 2009/03/26 Chest. 2009 Sep;136(3):716-725. doi: 10.1378/chest.08-2192. Epub 2009 Mar 24. PY - 2009 SN - 1931-3543 (Electronic) 0012-3692 (Linking) SP - 716-725 ST - Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents T2 - Chest TI - Chronic bronchitis, COPD, and lung function in farmers: the role of biological agents UR - https://www.ncbi.nlm.nih.gov/pubmed/19318669 VL - 136 ID - 71 ER - TY - JOUR AB - BACKGROUND: Occupational exposures are associated with chronic obstructive pulmonary disease (COPD). This study investigated this association among a population with a high prevalence of tuberculosis and smoking. METHODS: Cases (n=110) diagnosed by pulmonologists were selected from specialist respiratory clinics. Frequency sex- and age-matched controls (n=102) were selected from other clinics at the same institutions. Lifetime occupational exposure histories were obtained through interviews. Exposure variables derived from the ALOHA Job Exposure Matrix (JEM) were used to complement the self-reporting variables. ORs were calculated from logistic regression models, adjusting for smoking and past history of tuberculosis. Percentage population attributable risk (PAR%) was also calculated. RESULTS: The adjusted ORs for COPD from the JEM-derived high cumulative biological dust exposure, high cumulative mineral dust exposure and high cumulative gas and fumes exposure were 2.1 (95% CI 1.1 to 4.2), 1.1 (95% CI 0.6 to 2.4) and 1.8 (95% CI 0.8 to 3.9), respectively. Self-reported occupational exposures were associated with higher risks, with adjusted ORs for high dust exposure-years and high chemical, gas and fumes exposure-years of 5.9 (95% CI 2.6 to 13.2) and 3.6 (95% CI 1.6 to 7.9), respectively. Among ever smokers, there was an increased risk for COPD, with ORs ranging from 5.0 to 5.5. Tuberculosis was a strong risk factor, with an OR ranging from 7.7 to 8.1. The PAR% was 25% for self-reported high exposures, but lower when the JEM variables were used. CONCLUSIONS: Lifetime occupational exposures contribute to the risk of COPD, adjusted for smoking. These risks are present in populations with a high burden of tuberculosis, which is considered an important causative factor. AD - Department of Occupational and Environmental Health, George Campbell Building, University of KwaZulu-Natal, Durban 4041, South Africa. AN - 21502099 AU - Govender, N. AU - Lalloo, U. G. AU - Naidoo, R. N. C1 - 135 C2 - Govender 2011 DA - Jul DB - Medline DO - 10.1136/thx.2010.149468 DP - NLM ET - 20110417 IS - 7 KW - Aged Air Pollutants, Occupational/toxicity Dust/analysis Epidemiologic Methods Female Humans Male Middle Aged Occupational Diseases/*etiology Occupational Exposure/*adverse effects/analysis Pulmonary Disease, Chronic Obstructive/*etiology Smoking/adverse effects Tuberculosis/complications N1 - Govender, Nadira Lalloo, Umesh G Naidoo, Rajen N eng Multicenter Study Research Support, Non-U.S. Gov't England 2011/04/20 Thorax. 2011 Jul;66(7):597-601. doi: 10.1136/thx.2010.149468. Epub 2011 Apr 17. PY - 2011 SN - 1468-3296 (Electronic) 0040-6376 (Linking) SP - 597-601 ST - Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study T2 - Thorax TI - Occupational exposures and chronic obstructive pulmonary disease: a hospital based case-control study UR - https://www.ncbi.nlm.nih.gov/pubmed/21502099 VL - 66 ID - 59 ER - TY - JOUR AB - OBJECTIVES: Chronic Obstructive Pulmonary Disease (COPD) is a common respiratory disorder. Next to tobacco smoking, occupational exposure is the most important risk factor for COPD in high-income countries. To enable preventative measures, more knowledge is needed on which specific occupational exposures that are related to risk of developing COPD in men and women. METHODS: A population-based cohort was formed from subjects responding to the Stockholm Public Health Surveys in 2002, 2006, and 2010, followed up until 2014. The dataset was linked to a quantitative job exposure matrix via occupational titles from the 1990 nation-wide Population and housing census. We identified COPD among subjects having medication for COPD and/or reporting a physician's diagnosis of COPD. The gender-specific risks to develop COPD from occupational particle-exposure were estimated by proportional hazards regression model, adjusted for age and individual data on tobacco-smoking. RESULTS: Men exposed to respirable crystalline silica (RCS) (HR 1.46, CI 1.13-1.90), gypsum and insulation material (HR 1.56, CI 1.18-2.05), diesel exhaust (HR 1.18, CI 0.99-1.41) and high levels of particles from asphalt/bitumen (HR 1.71, CI 1.06-2.76) as well as welding fumes (HR 1.57, CI 1.12-2.21) had an increased smoking-adjusted risk for developing COPD. An increased risk was also observed among women highly exposed to various organic particles from soil, leather, plastic, soot, animal, textile, flour (HR 1.53, CI 1.15-2.04). Furthermore, a significant positive exposure-response trend was found among men exposed to RCS, iron dust, gypsum and insulation material, and diesel exhaust. A tendency towards an exposure-response relationship was also seen among both men and women exposed to welding fumes and various organic particles, and among men exposed to particles from asphalt/bitumen. The population attributable fraction for COPD from occupational exposure to particles was 10.6% among men and 6.1% among women. CONCLUSIONS: This study indicates an increased smoking-adjusted risk of developing of COPD due to occupational exposure to particles. A positive exposure-response relationship was found for RCS, gypsum and insulation, diesel exhaust, and welding fumes. Also, exposure to high levels of asphalt/bitumen and various organic particles was associated with a higher risk for COPD. Reduction of these exposures in the work environment are important to prevent future cases of COPD. More studies are needed to investigate exposure-response relationships further, but this study indicates that the European occupational exposure limit (OEL) for RCS needs to be re-evaluated. AD - Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden. Electronic address: karin.grahn@ki.se. Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden. Electronic address: per.gustavsson@ki.se. Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden. Electronic address: tomas.andersson@ki.se. Department of Respiratory Medicine and Allergology, NB6:03 Karolinska University Hospital, SE-171 76, Stockholm, Sweden; Institute of Environmental Medicine, Unit for Lung & Airway Research, Karolinska Institutet, PO Box 210, SE-171 77, Stockholm, Sweden. Electronic address: anders.linden@ki.se. Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden; Department of Public Health Sciences, Stockholm University, SE-106 91, Stockholm, Sweden. Electronic address: tomas.hemmingsson@ki.se. Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden. Electronic address: jenny.selander@ki.se. Institute of Environmental Medicine, Unit for Occupational Medicine, Karolinska Institutet, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden; Centre for Occupational and Environmental Medicine, Region Stockholm, Solnavagen 4, Plan 10, SE-113 65, Stockholm, Sweden. Electronic address: pernilla.wiebert@ki.se. AN - 34302831 AU - Grahn, K. AU - Gustavsson, P. AU - Andersson, T. AU - Linden, A. AU - Hemmingsson, T. AU - Selander, J. AU - Wiebert, P. C1 - 8465 C2 - Grahn 2021 DA - Sep DB - Medline DO - 10.1016/j.envres.2021.111739 DP - NLM ET - 20210721 KW - Cohort Studies Dust/analysis Female Humans Male *Occupational Diseases *Occupational Exposure/adverse effects *Pulmonary Disease, Chronic Obstructive/epidemiology/etiology Risk Factors Sweden/epidemiology Chronic obstructive pulmonary disease Dust Epidemiology Job exposure matrix Occupational exposure N1 - Grahn, Karin Gustavsson, Per Andersson, Tomas Linden, Anders Hemmingsson, Tomas Selander, Jenny Wiebert, Pernilla eng Research Support, Non-U.S. Gov't Netherlands 2021/07/25 Environ Res. 2021 Sep;200:111739. doi: 10.1016/j.envres.2021.111739. Epub 2021 Jul 21. PY - 2021 SN - 1096-0953 (Electronic) 0013-9351 (Linking) SP - 111739 ST - Occupational exposure to particles and increased risk of developing chronic obstructive pulmonary disease (COPD): A population-based cohort study in Stockholm, Sweden T2 - Environ Res TI - Occupational exposure to particles and increased risk of developing chronic obstructive pulmonary disease (COPD): A population-based cohort study in Stockholm, Sweden UR - https://www.ncbi.nlm.nih.gov/pubmed/34302831 VL - 200 ID - 83 ER - TY - JOUR AB - Exposure to ambient PM10 may increase the risk of chronic obstructive pulmonary disease (COPD) and lung function decline. We evaluated the long-term exposure to PM10 and its relationship with COPD prevalence and lung function in Parisian subway workers. Participants were randomly selected from a 15,000-subway worker cohort. Individual annual external exposure to PM10 (ePM10) was estimated using a company-specific job-exposure-matrix based on PM10 measurements conducted between 2004 and 2019 in the Parisian subway network. Mean annual inhaled PM10 exposure (iPM10) was modeled as function of ePM10 exposure, inhalation rate, and filtration efficiency of the respiratory protection used. COPD diagnosis was performed in March-May 2021 based on post-bronchodilator spirometry. The relationship between iPM10 and outcomes was assessed using logistic and linear regression models, adjusted for exposure duration and potential confounders. Amongst 254 participants with complete data, 17 were diagnosed as COPD. The mean employment duration was 23.2 +/- 7.3years, with annual mean ePM10 of 71.8 +/- 33.7 mug/m(3) and iPM10 of 0.59 +/- 0.27 mug/shift, respectively. A positive but statistically non-significant association was found for COPD prevalence with iPM10 (OR = 1.034, 95%-CI = 0.781; 1.369, per 100 ng/shift) and ePM10 (OR = 1.029, 95%-CI = 0.879; 1.207, per 10 mug/m(3)). No decline in lung function was associated with PM10 exposure. However, forced expiratory volume during the first second and forced vital capacity lower than normal were positively associated with exposure duration (OR = 1.125, 95%-CI = 1.004; 1.260 and OR = 1.171, 95%-CI = 0.989; 1.386 per year, respectively). Current smoking was strongly associated with COPD prevalence (OR = 6.85, 95%-CI = 1.87; 25.10) and most lung function parameters. This is the first study assessing the relationship between long-term exposure to subway PM10 and respiratory health in subway workers. The risk estimates related with subway PM10 exposure are compatible with those related to outdoor PM10 exposure in the large recent studies. Large cohorts of subway workers are necessary to confirm these findings. AD - Center from Primary Care and Public Health (Unisante), University of Lausanne, Switzerland. Electronic address: irina.guseva-canu@unisante.ch. Center from Primary Care and Public Health (Unisante), University of Lausanne, Switzerland. Faculty of Medicine, University of Geneva, Switzerland; SwissMedPro Health Services, Switzerland; Hopital de la Tour, Geneva, Switzerland. Autonomous Paris Transport Authority (RATP), Paris, France. AN - 38159498 AU - Guseva Canu, I. AU - Wild, P. AU - Charreau, T. AU - Freund, R. AU - Toto, A. AU - Pralong, J. AU - Sakthithasan, K. AU - Jouannique, V. AU - Debatisse, A. AU - Suarez, G. C1 - 9588 C2 - GusevaCanu 2024 DA - Mar DB - Medline DO - 10.1016/j.ijheh.2023.114316 DP - NLM ET - 20231230 KW - Humans *Air Pollution Particulate Matter/analysis *Railroads *Pulmonary Disease, Chronic Obstructive/epidemiology Smoking Forced Expiratory Volume Copd Inhalation Metro Occupational exposure Particles Spirometry N1 - Guseva Canu, Irina Wild, Pascal Charreau, Thomas Freund, Romain Toto, Antonio Pralong, Jacques Sakthithasan, Kirushanthi Jouannique, Valerie Debatisse, Amelie Suarez, Guillaume eng Germany 2024/01/02 Int J Hyg Environ Health. 2024 Mar;256:114316. doi: 10.1016/j.ijheh.2023.114316. Epub 2023 Dec 30. PY - 2024 SN - 1618-131X (Electronic) 1438-4639 (Linking) SP - 114316 ST - Long-term exposure to PM(10) and respiratory health among Parisian subway workers T2 - Int J Hyg Environ Health TI - Long-term exposure to PM(10) and respiratory health among Parisian subway workers UR - https://www.ncbi.nlm.nih.gov/pubmed/38159498 VL - 256 ID - 92 ER - TY - JOUR AB - OBJECTIVES: To investigate associations between respiratory disease and occupational exposures in a New Zealand urban population, the Wellington Respiratory Survey. METHODS: Multiple regression analyses in a population sample of 1017 individuals aged 25 to 74 years with spirometry and questionnaire information, including a lifetime occupational history. RESULTS: Chronic bronchitis symptoms were associated with self-reported exposure to hairdressing, paint manufacturing, insecticides, welding, detergents and with ALOHA Job Exposure Matrix-assessed gases/fumes exposure. The strongest association was for hairdressing (odds ratio 6.91; 95% confidence interval: 2.02 to 23.70). Cumulative exposure to mineral dust and gases/fumes was associated with higher FEV(1)% (forced expiratory volume in the first second of expiration) predicted. Analyses were limited by relatively small numbers of cases. CONCLUSIONS: Increased risks of objectively defined respiratory disease, which have been previously documented, were not seen. Nevertheless, the study suggested increased risk of respiratory symptoms with various occupational exposures as well as likely healthy worker effect. AD - From the MRC-PHE Centre for Environment and Health (Drs Hansell and Ghosh), Imperial College London, London, the United Kingdom; Imperial College Healthcare NHS Trust (Dr Hansell), London, the United Kingdom; Tauranga Hospital (Dr Poole), Tauranga, New Zealand; Centre for Research in Environmental Epidemiology (CREAL) (Dr Zock), Barcelona, Spain; Hospital del Mar Medical Research Institute (IMIM) (Dr Zock), Barcelona, Spain; CIBER Epidemiologia y Salud Publica (CIBERESP) (Dr Zock), Spain; University of Otago Wellington (Prof Weatherall), Wellington, New Zealand; Institute for Risk Assessment Sciences (Profs Vermeulen and Kromhout), Utrecht University, Utrecht, The Netherlands; Medical Research Institute of New Zealand (Dr Travers), Wellington, New Zealand; and University of Otago, North Dunedin, New Zealand (Prof Beasley). AN - 24327054 AU - Hansell, A. AU - Ghosh, R. E. AU - Poole, S. AU - Zock, J. P. AU - Weatherall, M. AU - Vermeulen, R. AU - Kromhout, H. AU - Travers, J. AU - Beasley, R. C1 - 8472 C2 - Hansell 2014 DA - Mar DB - Medline DO - 10.1097/01.jom.0000438382.33221.dc DP - NLM IS - 3 KW - Adult Aged Asbestos/toxicity Asthma/epidemiology Barbering Bronchitis, Chronic/diagnosis/*epidemiology/etiology/physiopathology Detergents/toxicity Dust Emphysema/diagnosis/epidemiology/etiology Female Forced Expiratory Volume Gases/toxicity Humans Inhalation Exposure/adverse effects/*statistics & numerical data Insecticides/toxicity Male Middle Aged New Zealand/epidemiology Occupational Diseases/*epidemiology/etiology/physiopathology Occupational Exposure/adverse effects/*statistics & numerical data Paint/toxicity Prevalence Pulmonary Disease, Chronic Obstructive/diagnosis/*epidemiology/etiology/physiopathology Risk Factors Self Report Sex Factors Socioeconomic Factors Solvents/toxicity Urban Population/statistics & numerical data Welding N1 - Hansell, Anna Ghosh, Rebecca E Poole, Suzanne Zock, Jan-Paul Weatherall, Mark Vermeulen, Roel Kromhout, Hans Travers, Justin Beasley, Richard eng G0801056/MRC_/Medical Research Council/United Kingdom 075833/WT_/Wellcome Trust/United Kingdom Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't 2013/12/12 J Occup Environ Med. 2014 Mar;56(3):270-80. doi: 10.1097/01.jom.0000438382.33221.dc. PY - 2014 SN - 1536-5948 (Electronic) 1076-2752 (Linking) SP - 270-80 ST - Occupational risk factors for chronic respiratory disease in a New Zealand population using lifetime occupational history T2 - J Occup Environ Med TI - Occupational risk factors for chronic respiratory disease in a New Zealand population using lifetime occupational history UR - https://www.ncbi.nlm.nih.gov/pubmed/24327054 VL - 56 ID - 84 ER - TY - JOUR AB - A recent article reported that occupational exposure to vapor-gas, dust, and fumes (VGDF) was more common in a sample of rural adults than in a sample of adults in urban settings. In another study of the same urban adults, airflow obstruction (AO) was associated with occupational VGDF and the combination of smoking and occupational exposure. The goal of the current study was to determine if similar associations were evident in the sample of rural adults. We analyzed enrollment data from the Keokuk County Rural Health Study (KCRHS), which investigated the health of rural residents in Iowa. We used the same methods as the study of urban adults. A job-exposure matrix (JEM) assigned an occupational VGDF exposure level based on each participants' last reported job. The health outcome was AO, defined as both the forced expiratory volume in one second (FEV1) and the FEV1/forced vital capacity (FVC) ratio < lower limit of normal. Of the 1699 KCRHS participants, 436 (25.7%) had high total VGDF occupational exposure, 661 (38.9%) had ever smoked cigarettes, and 110 (6.5%) had AO. The crude frequency of AO increased across the joint categories of smoking (never, ever) and high exposure (no, yes) (p < 0.05 for linear trend). After adjusting for potential confounders, AO was associated with high total occupational VGDF exposure only among smokers (OR = 1.81, 95% CI 1.002 to 3.26). In conclusion, the association of AO with occupational exposure in the current study of rural adults was similar to what was previously observed among urban adults. AD - Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA. Department of Occupational and Environmental Health, The University of Iowa, Iowa City, Iowa, USA. AN - 32586160 AU - Henneberger, P. K. AU - Humann, M. J. AU - Liang, X. AU - Doney, B. C. AU - Kelly, K. M. AU - Cox-Ganser, J. M. C1 - Disclosure of interest The authors report no conflict of interest. C2 - PMC7469627 DA - Aug DB - Medline DO - 10.1080/15412555.2020.1775187 DP - NLM ET - 20200625 IS - 4 KW - Adolescent Adult Aged Air Pollutants/*adverse effects Cross-Sectional Studies Female Forced Expiratory Volume Humans Iowa Male Middle Aged Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*epidemiology Risk Factors *Rural Health Smoking Spirometry Surveys and Questionnaires Vital Capacity Young Adult Airflow obstruction occupational exposure rural adults N1 - Henneberger, P K Humann, M J Liang, X Doney, B C Kelly, K M Cox-Ganser, J M eng CC999999/ImCDC/Intramural CDC HHS/ U50 OH007548/OH/NIOSH CDC HHS/ Research Support, U.S. Gov't, P.H.S. England 2020/06/27 COPD. 2020 Aug;17(4):401-409. doi: 10.1080/15412555.2020.1775187. Epub 2020 Jun 25. PY - 2020 SN - 1541-2563 (Electronic) 1541-2555 (Print) 1541-2563 (Linking) SP - 401-409 ST - The Association of Airflow Obstruction with Occupational Exposures in a Sample of Rural Adults in Iowa T2 - COPD TI - The Association of Airflow Obstruction with Occupational Exposures in a Sample of Rural Adults in Iowa UR - https://www.ncbi.nlm.nih.gov/pubmed/32586160 VL - 17 ID - 60 ER - TY - JOUR AB - BACKGROUND: Coke oven workers are regularly exposed to coke oven emissions (COE) and may be at risk of developing lung diseases. There is limited evidence for the link between exposure to COE and chronic obstructive pulmonary diseases (COPD). The aim of this study was to explore the dose-response relationship between COE exposure and COPD and to assess the interaction with cigarette smoking. METHODS: Seven hundred and twelve coke oven workers and 211 controls were investigated in southern China. Benzene soluble fraction (BSF) concentrations as a surrogate of COE were measured in representative personal samples and the individual cumulative COE exposure level was quantitatively estimated. Detailed information on smoking habits and respiratory symptoms was collected and spirometric tests were performed. RESULTS: The mean BSF levels at the top of two coking plants were 743.8 and 190.5 microg/m3, respectively, which exceed the OSHA standard (150 microg/m3). After adjusting for cigarette smoking and other risk factors, there was a significant dose-dependent reduction in lung function and increased risks of chronic cough/phlegm and COPD in coke oven workers. The odds ratio for COPD was 5.80 (95% confidence interval 3.13 to 10.76) for high level cumulative COE exposure (> or =1714.0 microg/m3-years) compared with controls. The interaction between COE exposure and smoking in COPD was significant. The risk of COPD in those with the highest cumulative exposure to COE and cigarette smoking was 58-fold compared with non-smokers not exposed to COE. CONCLUSION: Long term exposure to COE increases the risk of an interaction between COPD and cigarette smoking. AD - Department of Environmental and Occupational Health, Fudan University, Shanghai 200032, P R China. AN - 16467069 AU - Hu, Y. AU - Chen, B. AU - Yin, Z. AU - Jia, L. AU - Zhou, Y. AU - Jin, T. C1 - Competing interests: none declared. C2 - PMC2104593 DA - Apr DB - Medline DO - 10.1136/thx.2005.051524 DP - NLM ET - 20060207 IS - 4 KW - Adult Aged Air Pollutants, Occupational/*adverse effects/analysis Benzene/analysis Case-Control Studies China/epidemiology Coke Dose-Response Relationship, Drug Environmental Monitoring Epidemiological Monitoring Female Humans Inhalation Exposure Male Middle Aged Occupational Diseases/epidemiology/*etiology/physiopathology Occupational Exposure/*adverse effects/analysis Pulmonary Disease, Chronic Obstructive/epidemiology/*etiology/physiopathology Respiratory Function Tests Risk Factors Smoking/*adverse effects/epidemiology N1 - Hu, Y Chen, B Yin, Z Jia, L Zhou, Y Jin, T eng Research Support, Non-U.S. Gov't England 2006/02/10 Thorax. 2006 Apr;61(4):290-5. doi: 10.1136/thx.2005.051524. Epub 2006 Feb 7. PY - 2006 SN - 0040-6376 (Print) 1468-3296 (Electronic) 0040-6376 (Linking) SP - 290-5 ST - Increased risk of chronic obstructive pulmonary diseases in coke oven workers: interaction between occupational exposure and smoking T2 - Thorax TI - Increased risk of chronic obstructive pulmonary diseases in coke oven workers: interaction between occupational exposure and smoking UR - https://www.ncbi.nlm.nih.gov/pubmed/16467069 VL - 61 ID - 176 ER - TY - JOUR AB - BACKGROUND: The impact of grain dust exposure on lung functions of grain handlers in Nigeria has remained largely undocumented. Lung functions of wheat flourmill workers and control subjects were assessed, and the prevalence of lung function abnormalities was compared among the occupational groups. METHODS: Study subjects consisted of 91 flour-millers, 30 matched internal controls from the maintenance unit of the same flourmill factory and 121 matched external controls. A cross-sectional analytical design is utilized; data were collected using structured interviews, anthropometric measurements, spirometry, and area dust sampling. RESULTS: The flour-millers recorded significantly lower mean lung functions compared with control subjects (P < 0.05), for FEV(1) and FVC, when observed values were expressed as percentages of predicted normal values. Furthermore, 29% of flour-millers, compared with 15% of external controls and 10% of internal controls, presented with at least one abnormal test result of ventilatory function. CONCLUSIONS: The study concluded that wheat flour-mill workers in Nigeria are at an increased risk of developing abnormalities of lung functions compared with control subjects, and the dominant pattern of respiratory disease among them is airway obstruction. AD - Department of Community Health, Obafemi Awolowo University, Ile-Ife, Nigeria. AN - 16167348 AU - Ijadunola, K. T. AU - Erhabor, G. E. AU - Onayade, A. A. AU - Ijadunola, M. Y. AU - Fatusi, A. O. AU - Asuzu, M. C. C1 - 486 C2 - Ijadunola 2005 DA - Oct DB - Medline DO - 10.1002/ajim.20219 DP - NLM IS - 4 KW - Adult Case-Control Studies Cross-Sectional Studies Flour/*toxicity Food Industry Forced Expiratory Flow Rates Humans Inhalation Exposure/*adverse effects Lung Diseases/*epidemiology/etiology Male Nigeria/epidemiology Occupational Diseases/*epidemiology/etiology Occupational Exposure/*adverse effects Spirometry Triticum/*toxicity Vital Capacity N1 - Ijadunola, K T Erhabor, G E Onayade, A A Ijadunola, M Y Fatusi, A O Asuzu, M C eng Research Support, Non-U.S. Gov't 2005/09/17 Am J Ind Med. 2005 Oct;48(4):308-17. doi: 10.1002/ajim.20219. PY - 2005 SN - 0271-3586 (Print) 0271-3586 (Linking) SP - 308-17 ST - Pulmonary functions of wheat flour mill workers and controls in Ibadan, Nigeria T2 - Am J Ind Med TI - Pulmonary functions of wheat flour mill workers and controls in Ibadan, Nigeria UR - https://www.ncbi.nlm.nih.gov/pubmed/16167348 VL - 48 ID - 110 ER - TY - JOUR AB - PURPOSE: Tobacco smoking is the major risk factor for COPD, and it is common for other risk factors in never-smokers to be overlooked. We examined the prevalence of COPD among never-smokers in Australia and identified associated risk factors. METHODS: We used data from the Australia Burden of Obstructive Lung Disease (BOLD) study, a cross-section of people aged >/=40 years from six sites. Participants completed interviews and post-bronchodilator spirometry. COPD was primarily defined as an FEV(1)/FVC ratio <0.70 and secondarily as the ratio less than the lower limit of normal (LLN). RESULTS: The prevalence of COPD in the 1656 never-smokers who completed the study was 10.5% (95% CI: 9.1-12.1%) [ratio4.71 mg x yr x m(-3), respectively, compared with non-/low-exposed females. For females, a positive trend between wood dust exposure and the cumulative incidence proportion of FEV(1)/FVC <70% was suggested. In conclusion, in the present low-exposed cohort, female woodworkers had an accelerated decline in lung function, which may be clinically relevant. AD - Dept of Occupational Medicine, Region Hospital Skive, Denmark. gitte.jacobsen@sygehusviborg.dk AN - 17989115 AU - Jacobsen, G. AU - Schlunssen, V. AU - Schaumburg, I. AU - Taudorf, E. AU - Sigsgaard, T. C1 - 300 C2 - Jacobsen 2008 DA - Feb DB - Medline DO - 10.1183/09031936.00146806 DP - NLM ET - 20071107 IS - 2 KW - Adult Air Pollutants, Occupational/adverse effects Case-Control Studies Denmark/epidemiology Dust Environmental Monitoring Epidemiological Monitoring Female Follow-Up Studies Forced Expiratory Volume Humans *Industry Inhalation Exposure/*adverse effects Linear Models Longitudinal Studies Male Middle Aged Occupational Exposure/*adverse effects Pneumoconiosis/prevention & control Probability Reference Values Respiratory Function Tests Risk Assessment Surveys and Questionnaires Wood/*adverse effects N1 - Jacobsen, G Schlunssen, V Schaumburg, I Taudorf, E Sigsgaard, T eng England 2007/11/09 Eur Respir J. 2008 Feb;31(2):334-42. doi: 10.1183/09031936.00146806. Epub 2007 Nov 7. PY - 2008 SN - 1399-3003 (Electronic) 0903-1936 (Linking) SP - 334-42 ST - Longitudinal lung function decline and wood dust exposure in the furniture industry T2 - Eur Respir J TI - Longitudinal lung function decline and wood dust exposure in the furniture industry UR - https://www.ncbi.nlm.nih.gov/pubmed/17989115 VL - 31 ID - 101 ER - TY - JOUR AB - BACKGROUND: Occupational exposure is estimated to contribute 15% to the burden of chronic obstructive pulmonary disease (COPD). Welding fumes are suspected to accelerate the decline of lung function and development of COPD. AIMS: To examine the relationship between welding fume exposure and COPD in Korean shipyard welders. METHODS: The study involved a group of male welders working at two shipyards who underwent an annual health examination in 2010. Subjects completed a questionnaire about smoking habits and occupational history and a pulmonary function test (PFT) was carried out with strict quality control measures. Welding fume exposure concentrations were estimated using 884 measurements taken between 2002 and 2009 in one of the shipyards. Multiple linear and logistic regression was employed to evaluate the association between cumulative fume exposure and lung function parameters, controlling for age, height and cigarette smoking. RESULTS: Two hundred and forty subjects participated, with a mean age of 48 and mean work duration of 15 years. The mean cumulative fume exposure was 7.7mg/m(3). The prevalence of COPD was 15%. FEV1 and FVC showed non-significant negative correlations with cumulative fume exposure. Odds ratios of COPD were significantly elevated for the middle (3.9; 95% CI 1.4-13.3) and high exposure groups (3.8; 95% CI 1.03-16.2) compared with the low fume exposure group. CONCLUSIONS: Our findings support an association between welding fume exposure and increased risk of COPD. Further prospective study is needed to investigate whether this is a causal relationship. AD - National Cancer Control Institute, National Cancer Center, Goyang 410-769, Korea. Department of Occupational and Environmental Medicine, Dong-A University, Busan 602-715, Korea, kimji@dau.ac.kr. Department of Occupational and Environmental Medicine, Busan Paik Hospital, Inje University, Busan 614-735, Korea. Occupational Safety and Health Research Institute, Korea Occupational Safety and Health Agency, Incheon 403-711, Korea. AN - 25324483 AU - Koh, D. H. AU - Kim, J. I. AU - Kim, K. H. AU - Yoo, S. W. AU - Korea Welders Cohort, Group C1 - 147 C2 - Koh 2015 DA - Jan DB - Medline DO - 10.1093/occmed/kqu136 DP - NLM ET - 20141016 IS - 1 KW - Adult Gases/*adverse effects Humans Inhalation Exposure/adverse effects/*statistics & numerical data Male Middle Aged Occupational Diseases/epidemiology Occupational Exposure/adverse effects/*statistics & numerical data Prospective Studies Pulmonary Disease, Chronic Obstructive/*epidemiology/etiology Surveys and Questionnaires *Welding Chronic obstructive pulmonary disease metal fume occupation welder welding. N1 - Koh, D-H Kim, J-I Kim, K-H Yoo, S-W eng Research Support, Non-U.S. Gov't England 2014/10/18 Occup Med (Lond). 2015 Jan;65(1):72-7. doi: 10.1093/occmed/kqu136. Epub 2014 Oct 16. PY - 2015 SN - 1471-8405 (Electronic) 0962-7480 (Linking) SP - 72-7 ST - Welding fume exposure and chronic obstructive pulmonary disease in welders T2 - Occup Med (Lond) TI - Welding fume exposure and chronic obstructive pulmonary disease in welders UR - https://www.ncbi.nlm.nih.gov/pubmed/25324483 VL - 65 ID - 61 ER - TY - JOUR AB - The impact of occupational dust and gas/fume exposure on chronic obstructive pulmonary disease (COPD) in developing countries has not been quantified. We examined the relationship between past dust and fume exposure and prevalence of COPD and respiratory symptoms in a cross-sectional analysis of a large Chinese population sample. Participants in the Guangzhou Biobank Cohort Study (n = 8216; 27.3% men, mean age 61.9 +/- 6.8 years) had spirometry and a structured interview including exposures, symptoms, and lifestyle. Self-reported intensity and duration of dust and gas/fume exposure was used to derive cumulative exposure. COPD was diagnosed from spirometry using lower limit of normal based on prediction equations. COPD was associated with high exposure to dust or gas/fume (exposed: 87/1206 v non-exposed: 191/3853; adjusted odds ratio: 1.41; 95% confidence interval (CI) 1.06, 1.87) with no evidence of effect modification by smoking. Respiratory symptoms were associated with exposures to dust and gas/fume, with adjusted odds ratios for chronic cough/phlegm of 1.57 (1.13, 2.17) and 1.39 (1.20, 1.60) for dyspnoea. The overall population attributable fraction for COPD due to occupational exposure was 10.4% (95% CI -0.9%, 19.5%). Occupational dust and gas/fume exposure is associated with an increased prevalence of COPD in this Chinese sample, independent of smoking. The population attributable fraction in Chinese is similar to that in Western populations. AD - Institute of Occupational and Environmental Medicine, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. AN - 22795505 AU - Lam, K. B. AU - Yin, P. AU - Jiang, C. Q. AU - Zhang, W. S. AU - Adab, P. AU - Miller, M. R. AU - Thomas, G. N. AU - Ayres, J. G. AU - Lam, T. H. AU - Cheng, K. K. C1 - 398 C2 - Lam 2012 DA - Oct DB - Medline DO - 10.1016/j.rmed.2012.05.009 DP - NLM ET - 20120712 IS - 10 KW - China/epidemiology Cohort Studies Cross-Sectional Studies *Dust Female Forced Expiratory Volume/physiology Gases/*toxicity Humans Male Middle Aged Occupational Diseases/*epidemiology/physiopathology Occupational Exposure/*adverse effects/statistics & numerical data Prevalence Prognosis Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology Vital Capacity/physiology N1 - Lam, Kin Bong Hubert Yin, Peng Jiang, Chao Qiang Zhang, Wei Sen Adab, Peymane Miller, Martin R Thomas, G Neil Ayres, Jon G Lam, Tai Hing Cheng, Kar Keung eng Research Support, Non-U.S. Gov't England 2012/07/17 Respir Med. 2012 Oct;106(10):1421-8. doi: 10.1016/j.rmed.2012.05.009. Epub 2012 Jul 12. PY - 2012 SN - 1532-3064 (Electronic) 0954-6111 (Linking) SP - 1421-8 ST - Past dust and GAS/FUME exposure and COPD in Chinese: the Guangzhou Biobank Cohort Study T2 - Respir Med TI - Past dust and GAS/FUME exposure and COPD in Chinese: the Guangzhou Biobank Cohort Study UR - https://www.ncbi.nlm.nih.gov/pubmed/22795505 VL - 106 ID - 159 ER - TY - JOUR AB - BACKGROUND: Never smokers comprise a substantial proportion of patients with COPD. Their characteristics and possible risk factors in this population are not yet well defined. METHODS: We analyzed data from 14 countries that participated in the international, population-based Burden of Obstructive Lung Disease (BOLD) study. Participants were aged >/= 40 years and completed postbronchodilator spirometry testing plus questionnaires about respiratory symptoms, health status, and exposure to COPD risk factors. A diagnosis of COPD was based on the postbronchodilator FEV(1)/FVC ratio, according to current GOLD (Global Initiative for Obstructive Lung Disease) guidelines. In addition to this, the lower limit of normal (LLN) was evaluated as an alternative threshold for the FEV(1)/FVC ratio. RESULTS: Among 4,291 never smokers, 6.6% met criteria for mild (GOLD stage I) COPD, and 5.6% met criteria for moderate to very severe (GOLD stage II+) COPD. Although never smokers were less likely to have COPD and had less severe COPD than ever smokers, never smokers nonetheless comprised 23.3% (240/1,031) of those classified with GOLD stage II+ COPD. This proportion was similar, 20.5% (171/832), even when the LLN was used as a threshold for the FEV(1)/FVC ratio. Predictors of COPD in never smokers include age, education, occupational exposure, childhood respiratory diseases, and BMI alterations. CONCLUSION: This multicenter international study confirms previous evidence that never smokers comprise a substantial proportion of individuals with COPD. Our data suggest that, in addition to increased age, a prior diagnosis of asthma and, among women, lower education levels are associated with an increased risk for COPD among never smokers. AD - Department of Pulmonary Medicine, Paracelsus Medical University, Salzburg, Austria. Electronic address: b.lamprecht@salk.at. Kaiser Permanente Center for Health Research, University, Portland. Department of Respiratory Medicine, Allergy, and Sleep, Landspitali University Hospital, Reykjavik, Iceland. Department of Respiratory Medicine, Hannover Medical University, Hannover, Germany. Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland. Department of Pulmonary Medicine, Paracelsus Medical University, Salzburg, Austria. University of Cape Town, Cape Town, South Africa. Centre for Research in Environmental Epidemiology, Barcelona, Spain. Department of Public Health Sciences, King's College London, London, England. University of Kentucky, Lexington, KY. Oregon Health and Science University, Portland. AN - 20884729 AU - Lamprecht, B. AU - McBurnie, M. A. AU - Vollmer, W. M. AU - Gudmundsson, G. AU - Welte, T. AU - Nizankowska-Mogilnicka, E. AU - Studnicka, M. AU - Bateman, E. AU - Anto, J. M. AU - Burney, P. AU - Mannino, D. M. AU - Buist, S. A. AU - Group, Bold Collaborative Research C1 - 399 C2 - PMC3168866 DA - Apr DB - Medline DO - 10.1378/chest.10-1253 DP - NLM ET - 20100930 IS - 4 KW - Adult Aged Aged, 80 and over Female Global Health Humans Incidence Male Middle Aged Pulmonary Disease, Chronic Obstructive/*epidemiology/physiopathology Respiratory Function Tests Retrospective Studies Risk Factors *Smoking Surveys and Questionnaires N1 - Lamprecht, Bernd McBurnie, Mary Ann Vollmer, William M Gudmundsson, Gunnar Welte, Tobias Nizankowska-Mogilnicka, Ewa Studnicka, Michael Bateman, Eric Anto, Josep M Burney, Peter Mannino, David M Buist, Sonia A eng Comparative Study Multicenter Study Research Support, Non-U.S. Gov't 2010/10/05 Chest. 2011 Apr;139(4):752-763. doi: 10.1378/chest.10-1253. Epub 2010 Sep 30. PY - 2011 SN - 1931-3543 (Electronic) 0012-3692 (Print) 0012-3692 (Linking) SP - 752-763 ST - COPD in never smokers: results from the population-based burden of obstructive lung disease study T2 - Chest TI - COPD in never smokers: results from the population-based burden of obstructive lung disease study UR - https://www.ncbi.nlm.nih.gov/pubmed/20884729 VL - 139 ID - 72 ER - TY - JOUR AB - INTRODUCTION: The aim of this study was to analyze the impact of occupational exposure on chronic obstructive pulmonary disease (COPD) and respiratory symptoms in the general Spanish population. METHODS: This was a study nested in the Spanish EPISCAN II cross-sectional epidemiological study that included participants who had completed a structured questionnaire on their occupational history, a questionnaire on respiratory symptoms, and forced spirometry. The data were analyzed using Chi-square and Student's t tests and adjusted models of multiple linear regression and logistic regression. RESULTS: We studied 7502 subjects, 51.1% women, with a mean age of 60+/-11 years. Overall, 53.2% reported some respiratory symptoms, 7.9% had respiratory symptoms during their work activity, 54.2% were or had been smokers, and 11.3% (851 subjects) met COPD criteria on spirometry. A total of 3056 subjects (40.7%) reported exposure to vapors, gases, dust or fumes (VGDF); occupational exposure to VGDF was independently associated with the presence of COPD (OR 1.22, 95% CI: 1.03-1.44), respiratory symptoms (OR 1.45, 95%: CI 1.30-1.61), and respiratory symptoms at work (OR 4.69, 95% CI: 3.82-5.77), with a population attributable fraction for COPD of 8.2%. CONCLUSIONS: Occupational exposure is associated with a higher risk of COPD and respiratory symptoms in the Spanish population. These results highlight the need to follow strict prevention measures to protect the respiratory health of workers. AD - Departamento de Medicina, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; Servicio de Neumologia, Centro Medico Teknon, Grupo Quironsalud, Barcelona, Spain. Instituto Nacional de Salud Publica y Medio Ambiente (RIVM), Bilthoven, The Netherlands. Servicio de Neumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain. Departamento de Medicina, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; Servicio de Neumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Servicio de Neumologia, Hospital Arnau de Vilanova-Lliria, Departamento de Medicina, Universitat de Valencia, Valencia, Spain. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Servicio de Neumologia, Hospital Universitario La Princesa, Universidad Autonoma de Madrid, Madrid, Spain. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Servicio de Neumologia, Hospital Universitario La Paz-IdiPAZ, Universidad Autonoma de Madrid, Madrid, Spain. Servicio de Neumologia, Hospital General Gregorio Maranon, Madrid, Spain. Unidad de Gestion Clinica de Neumologia, Hospital Universitario Virgen de Valme, Universidad de Sevilla, Sevilla, Spain. Servicio de Neumologia-Unidad de Investigacion Hospital Universitario Nuestra Senora de Candelaria, CIBERES, ISCIII, Universidad de La Laguna, Tenerife, Spain. Servicio de Neumologia, Hospital Universitario Vithas Madrid Arturo Soria, Universidad Europea (UE), Madrid, Spain. Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Servicio de Neumologia, Hospital Universitario Son Espases-IdISBa, Departamento de Medicina, Universidad de las Islas Baleares, Palma de Mallorca, Spain. Departamento de Medicina, Universitat Autonoma de Barcelona (UAB), Barcelona, Spain; Servicio de Neumologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. Electronic address: jaimejuan.ferrer@vallhebron.cat. AN - 38176851 AU - Loeb, E. AU - Zock, J. P. AU - Miravitlles, M. AU - Rodriguez, E. AU - Soler-Cataluna, J. J. AU - Soriano, J. B. AU - Garcia-Rio, F. AU - de Lucas, P. AU - Alfageme, I. AU - Casanova, C. AU - Rodriguez Gonzalez-Moro, J. M. AU - Ancochea, J. AU - Cosio, B. G. AU - Ferrer Sancho, J. C1 - 9662 C2 - Loeb 2024 DA - Jan DB - Medline DO - 10.1016/j.arbres.2023.10.014 DP - NLM ET - 20231119 IS - 1 KW - Humans Female Middle Aged Aged Male Cross-Sectional Studies *Pulmonary Disease, Chronic Obstructive/epidemiology/etiology/diagnosis *Occupational Exposure/adverse effects Gases Spirometry Dust *Occupational Diseases/epidemiology/etiology Risk Factors Chronic obstructive pulmonary disease Occupational exposure Respiratory symptoms N1 - Loeb, Eduardo Zock, Jan-Paul Miravitlles, Marc Rodriguez, Esther Soler-Cataluna, Juan Jose Soriano, Joan B Garcia-Rio, Francisco de Lucas, Pilar Alfageme, Inmaculada Casanova, Ciro Rodriguez Gonzalez-Moro, Jose Miguel Ancochea, Julio Cosio, Borja G Ferrer Sancho, Jaume eng spa Spain 2024/01/05 Arch Bronconeumol. 2024 Jan;60(1):16-22. doi: 10.1016/j.arbres.2023.10.014. Epub 2023 Nov 19. PY - 2024 SN - 1579-2129 (Electronic) 0300-2896 (Linking) SP - 16-22 ST - Association between occupational exposure and chronic obstructive pulmonary disease and respiratory symptoms in the Spanish population T2 - Arch Bronconeumol TI - Association between occupational exposure and chronic obstructive pulmonary disease and respiratory symptoms in the Spanish population UR - https://www.ncbi.nlm.nih.gov/pubmed/38176851 VL - 60 ID - 93 ER - TY - JOUR AB - BACKGROUND: Occupational exposures have been associated with an increased risk of COPD. However, few studies have related objectively assessed occupational exposures to prospectively assessed incidence of COPD, using postbronchodilator lung function tests. Our objective was to examine the effect of occupational exposures on COPD incidence in the European Community Respiratory Health Survey. METHODS: General population samples aged 20-44 were randomly selected in 1991-1993 and followed up 20 years later (2010-2012). Spirometry was performed at baseline and at follow-up, with incident COPD defined using a lower limit of normal criterion for postbronchodilator FEV1/FVC. Only participants without COPD and without current asthma at baseline were included. Coded job histories during follow-up were linked to a Job-Exposure Matrix, generating occupational exposure estimates to 12 categories of agents. Their association with COPD incidence was examined in log-binomial models fitted in a Bayesian framework. FINDINGS: 3343 participants fulfilled the inclusion criteria; 89 of them had COPD at follow-up (1.4 cases/1000 person-years). Participants exposed to biological dust had a higher incidence of COPD compared with those unexposed (relative risk (RR) 1.6, 95% CI 1.1 to 2.3), as did those exposed to gases and fumes (RR 1.5, 95% CI 1.0 to 2.2) and pesticides (RR 2.2, 95% CI 1.1 to 3.8). The combined population attributable fraction for these exposures was 21.0%. INTERPRETATION: These results substantially strengthen the evidence base for occupational exposures as an important risk factor for COPD. AD - Barcelona Institute of Global Health (ISGlobal), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain. IRAS, University of Utrecht, Utrecht, The Netherlands. Department of Epidemiology and Social Medicine (ESOC), Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. StatUA Statistics Centre, University of Antwerp, Antwerp, Belgium. Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, University Hospital of Ludwig Maximilians University, Comprehensive Pneumology Centre Munich, German Centre for Lung Research, Munich, Germany. Pulmonology Department, Galdakao Hospital, Bizkaia, Spain. Servicio de Neumologia, Complejo Hospitalario Universitario, Albacete, Spain. Facultad de Medicina Albacete, Universidad de Castilla-La Mancha, Ciudad Real, Spain. Respiratory Department, Hospital Universitario San Agustin, Aviles, Spain. Respiratory and Allergy Clinical Unit, Universitary Hospitalary Complex, Huelva, Spain. Universite de Bordeaux, Inserm, Bordeaux Population Health Research Center, team EPICENE, UMR 1219, Bordeaux, France. Department of Pediatrie, CHU de Grenoble Alpes, Grenoble, France. Inserm, U1209, IAB, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, Grenoble, France. Universite Grenoble Alpes, Grenoble, France. University Hospital of Montpellier, Montpellier, France. Sorbonne Universites, Paris, France. Inserm UMR 1152-Equipe Epidemiologie, Universite Paris Diderot, Paris, France. Department of Health Sciences, Experimental and Forensic Medicine - Unit of Biostatistics and Clinical Epidemiology, University of Pavia, Pavia, Italy. Department of Respiratory Medicine and Sleep, Landspitali University Hospital, Reykjavik, Iceland. Faculty of Medicine, University of Iceland, Reykjavik, Iceland. Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway. Centre for International Health, University of Bergen, Bergen, Norway. Department of Occupational and Environmental Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umea University, Umea, Sweden. Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Research and Evaluation Office, Boston Public Health Commission, Boston, Massachusetts, USA. Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland. University of Basel, Basel, Switzerland. Monash Centre for Occupation and Environmental Health, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. Lung Clinic, Tartu University Hospital, Tartu, Estonia. Section of Occupational and Environmental Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. Department of Public Health, Section for Environment, Occupation and Health, Danish Ramazzini Center, Aarhus University, Aarhus, Denmark. National Research Center for the Working Environment, Copenhagen, Denmark. Unit of Occupational Medicine, University Hospital of Verona, Verona, Italy. University of California San Francisco, San Francisco Veterans Affairs Medical Center, San Francisco, California, USA. Population Health and Occupational Disease, National Heart and Lung Institute, Imperial College London, London, UK. MRC-PHE Centre for Environment and Health, Imperial College London, London, UK. AN - 29574416 AU - Lytras, T. AU - Kogevinas, M. AU - Kromhout, H. AU - Carsin, A. E. AU - Anto, J. M. AU - Bentouhami, H. AU - Weyler, J. AU - Heinrich, J. AU - Nowak, D. AU - Urrutia, I. AU - Martinez-Moratalla, J. AU - Gullon, J. A. AU - Pereira-Vega, A. AU - Raherison-Semjen, C. AU - Pin, I. AU - Demoly, P. AU - Leynaert, B. AU - Villani, S. AU - Gislason, T. AU - Svanes, C. AU - Holm, M. AU - Forsberg, B. AU - Norback, D. AU - Mehta, A. J. AU - Probst-Hensch, N. AU - Benke, G. AU - Jogi, R. AU - Toren, K. AU - Sigsgaard, T. AU - Schlunssen, V. AU - Olivieri, M. AU - Blanc, P. D. AU - Vermeulen, R. AU - Garcia-Aymerich, J. AU - Jarvis, D. AU - Zock, J. P. C1 - Competing interests: None declared. C2 - Lytras 2018 DA - Nov DB - Medline DO - 10.1136/thoraxjnl-2017-211158 DP - NLM ET - 20180324 IS - 11 KW - Adult Australia/epidemiology Europe/epidemiology Female Follow-Up Studies *Forecasting Health Surveys/*methods Humans Incidence Male Occupational Diseases/*complications/epidemiology Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*epidemiology/etiology Respiratory Function Tests Retrospective Studies Risk Factors Young Adult copd epidemiology occupational lung disease N1 - Lytras, Theodore Kogevinas, Manolis Kromhout, Hans Carsin, Anne-Elie Anto, Josep M Bentouhami, Hayat Weyler, Joost Heinrich, Joachim Nowak, Dennis Urrutia, Isabel Martinez-Moratalla, Jesus Gullon, Jose Antonio Pereira-Vega, Antonio Raherison-Semjen, Chantal Pin, Isabelle Demoly, Pascal Leynaert, Benedicte Villani, Simona Gislason, Thorarinn Svanes, Cecilie Holm, Mathias Forsberg, Bertil Norback, Dan Mehta, Amar J Probst-Hensch, Nicole Benke, Geza Jogi, Rain Toren, Kjell Sigsgaard, Torben Schlunssen, Vivi Olivieri, Mario Blanc, Paul D Vermeulen, Roel Garcia-Aymerich, Judith Jarvis, Deborah Zock, Jan-Paul eng G0901214/MRC_/Medical Research Council/United Kingdom 92091/Medical Research Council/United Kingdom WT 084703MA/Wellcome Trust/United Kingdom Department of Health/United Kingdom Multicenter Study Research Support, Non-U.S. Gov't England 2018/03/27 Thorax. 2018 Nov;73(11):1008-1015. doi: 10.1136/thoraxjnl-2017-211158. Epub 2018 Mar 24. PY - 2018 SN - 1468-3296 (Electronic) 0040-6376 (Linking) SP - 1008-1015 ST - Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey T2 - Thorax TI - Occupational exposures and 20-year incidence of COPD: the European Community Respiratory Health Survey UR - https://www.ncbi.nlm.nih.gov/pubmed/29574416 VL - 73 ID - 85 ER - TY - JOUR AB - Chronic obstructive pulmonary disease (COPD) was the third leading cause of death worldwide in 2019, with a significant disease burden. We conducted a nested case-control study using data from the China Metal-Exposed Workers Cohort Study (Jinchang Cohort) and assessed the associations of exposure to metals and tobacco smoking with the risk of COPD. We used the logistic regression model and the interaction multiplication model to assess the independent and combined effects of heavy metal and smoke exposure on COPD. The cumulative incidence of COPD was 1.04% in 21,560 participants during a median of two years of follow-up. The risk of COPD was significantly elevated with an increase in the amount of tobacco smoked daily (p < 0.05), the number of years of smoking (p(trend) < 0.05), and the number of packs of cigarettes smoked per year (p(trend) < 0.01). Compared with the low metal exposure group, the adjusted OR was 1.22 (95% CI: 0.85-1.76) in the medium exposure group (mining/production workers) and 1.50 (95% CI: 1.03-2.18) in the high exposure group; smoking and metal exposure had a combined effect on the incidence of COPD (p(interaction) < 0.01), with an OR of 4.60 for those with >40 pack-years of smoking who also had the highest metal exposures. Both exposures to metals and smoking were associated with the risk of COPD, and there was an interaction between the two exposures for the risk of COPD. AD - School of Public Health, Lanzhou University, Lanzhou 730000, China. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China. AN - 36078612 AU - Ma, L. AU - Huo, X. AU - Yang, A. AU - Yu, S. AU - Ke, H. AU - Zhang, M. AU - Bai, Y. C1 - The authors declare no conflict of interest. C2 - PMC9518333 DA - Sep 1 DB - Medline DO - 10.3390/ijerph191710896 DP - NLM ET - 20220901 IS - 17 KW - Case-Control Studies Cohort Studies Humans *Metals, Heavy/toxicity *Occupational Exposure/adverse effects/analysis *Pulmonary Disease, Chronic Obstructive/epidemiology/etiology Risk Factors Smoking/adverse effects/epidemiology Tobacco Smoking Copd association interaction metals smoking N1 - Ma, Li Huo, Xinxin Yang, Aimin Yu, Shuxia Ke, Hongxia Zhang, Mingxia Bai, Yana eng Research Support, Non-U.S. Gov't Switzerland 2022/09/10 Int J Environ Res Public Health. 2022 Sep 1;19(17):10896. doi: 10.3390/ijerph191710896. PY - 2022 SN - 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) ST - Metal Exposure, Smoking, and the Risk of COPD: A Nested Case-Control Study in a Chinese Occupational Population T2 - Int J Environ Res Public Health TI - Metal Exposure, Smoking, and the Risk of COPD: A Nested Case-Control Study in a Chinese Occupational Population UR - https://www.ncbi.nlm.nih.gov/pubmed/36078612 VL - 19 ID - 80 ER - TY - JOUR AB - RATIONALE: Although occupational exposure to dust and fumes is considered a risk factor for chronic obstructive pulmonary disease, this determination has been limited by reliance on spirometry alone to assess disease severity in predominantly male populations. OBJECTIVES: To determine the effect of occupational exposure on lung function, respiratory symptoms, and findings of emphysema and airway wall thickness measured using quantitative computed tomography in men and women. METHODS: COPDGene is a multicenter study of current and former smokers that underwent standardized volumetric chest computed tomography scans to assess airways, % emphysema, and % gas trapping. Spirometry and a respiratory questionnaire including occupational history were also analyzed in 9,614 subjects (4,496 women). Logistic regression and analysis of covariance was used to assess associations with exposure. MEASUREMENTS AND MAIN RESULTS: Occupational exposure to both dust and fumes was reported by 47.9% of men and 20.1% of women. Adjusting for age, race, body mass index, education, and current and lifetime smoking, the odds ratios for persons with dust and fume exposures for chronic cough, chronic phlegm, persistent wheeze, and Global Initiative for Chronic Obstructive Lung Disease stages 2 and higher chronic obstructive pulmonary disease were significantly elevated and similar for men (1.83, 1.84, 2.0, 1.61, respectively) and women (1.65, 1.82, 1.98, 1.90, respectively). The % predicted FEV1 was similarly lower in those with exposure in men (70.7 +/- 0.8 vs. 76.0 +/- 0.9; P < 0.001) and women (70.5 +/- 0.8 vs. 77.2 +/- 0.8; P < 0.001). Percent emphysema and gas trapping was greater in those exposed to dust and fumes in men and women. In men, but not in women, persons with exposure had a greater mean square root wall area of 10-mm internal perimeter airways. CONCLUSIONS: Occupational exposure to dust and fumes in men and women is similarly associated with airflow obstruction, respiratory symptoms, more emphysema, and gas trapping in men and women. AD - 1 Department of Medicine, Temple University School of Medicine, Philadelphia, Pennsylvania. AN - 25133327 AU - Marchetti, N. AU - Garshick, E. AU - Kinney, G. L. AU - McKenzie, A. AU - Stinson, D. AU - Lutz, S. M. AU - Lynch, D. A. AU - Criner, G. J. AU - Silverman, E. K. AU - Crapo, J. D. AU - Investigators, C. OPDGene C1 - 406 C2 - PMC4299608 DA - Oct 1 DB - Medline DO - 10.1164/rccm.201403-0493OC DP - NLM IS - 7 KW - Analysis of Variance Female Forced Expiratory Volume Humans Lung/*diagnostic imaging/*physiopathology Male Middle Aged Occupational Exposure/*statistics & numerical data Odds Ratio Pulmonary Disease, Chronic Obstructive/*diagnostic imaging/*physiopathology Pulmonary Emphysema/diagnostic imaging/physiopathology Respiratory Physiological Phenomena Risk Factors Sex Distribution Smoking Spirometry Surveys and Questionnaires Tomography, X-Ray Computed/*methods Copd emphysema occupational exposure N1 - Marchetti, Nathaniel Garshick, Eric Kinney, Gregory L McKenzie, Alex Stinson, Douglas Lutz, Sharon M Lynch, David A Criner, Gerard J Silverman, Edwin K Crapo, James D eng R01 HL089856/HL/NHLBI NIH HHS/ R01 HL089897/HL/NHLBI NIH HHS/ T32 ES007142/ES/NIEHS NIH HHS/ Multicenter Study Research Support, N.I.H., Extramural 2014/08/19 Am J Respir Crit Care Med. 2014 Oct 1;190(7):756-62. doi: 10.1164/rccm.201403-0493OC. PY - 2014 SN - 1535-4970 (Electronic) 1073-449X (Print) 1073-449X (Linking) SP - 756-62 ST - Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene T2 - Am J Respir Crit Care Med TI - Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene UR - https://www.ncbi.nlm.nih.gov/pubmed/25133327 VL - 190 ID - 160 ER - TY - JOUR AB - BACKGROUND: Recent community surveys have reported a risk of chronic obstructive pulmonary disease (COPD) in occupations involving exposure to organic dust and gas/vapour. Aims Our aim was to confirm these results using a case-control design on 131 COPD cases (FEV(1) < 80% of predicted value, minimally reversible with bronchodilators) and 298 controls, selected from registers for patients admitted to our Institute of Occupational Medicine. METHODS: Surrogates of past exposure were occupation, exposure assigned by a job-exposure matrix, and years spent in a given occupation. The odds ratio (OR) and 95% confidence interval (CI) for COPD were calculated using logistic regression models with office workers as the reference. RESULTS: Age-smoking-adjusted ORs (and CIs) were: 15.1 (3.2-71.6) in farmers; 7.2 (1.3-41.1) in cotton workers; 6.4 (1.6-25.5) in welders; 4.7 (1.3-16.4) in painters; 12.1 (1.3-108) in foundry workers; 6.50 (1.14-37.0) in refractory brick workers; and 3.1 (1.0-9.5) in construction workers. In farmers, cotton workers, welders and painters, the adjusted ORs significantly increased (by 6-9%) for each extra year of work, while in other occupations any such increase was of borderline significance. Adjusted ORs were 3.80 (1.21-12.0), 5.83 (1.82-18.6) and 8.86 (2.29-34.3) in workers exposed to high levels of mineral dust, gas/vapour/fume and biological dust, respectively. Consistent risk estimates were obtained for farmers, textile workers, painters and welders. CONCLUSIONS: Our findings confirm previous epidemiological evidence and are supported by recent observations that cigarette smoke, cotton and organic farm dust contain the same powerful pro-inflammatory agents, and that organic dust and irritant gas induce bronchitis by triggering the same effector molecules as cigarette smoke. AD - Department of Environmental Medicine and Public Health-Section of Occupational Medicine, University of Padua, Via Giustiniani 2, I-35128 Padova, Italy. giuseppe.mastrangelo@unipd.it AN - 12724550 AU - Mastrangelo, G. AU - Tartari, M. AU - Fedeli, U. AU - Fadda, E. AU - Saia, B. C1 - 407 C2 - Mastrangelo 2003 DA - May DB - Medline DO - 10.1093/occmed/kqg041 DP - NLM IS - 3 KW - Adult Aged Case-Control Studies *Dust Female Gases/*adverse effects Humans Italy/epidemiology Logistic Models Male Occupational Diseases/epidemiology/*etiology Occupational Exposure/*adverse effects Odds Ratio Pulmonary Disease, Chronic Obstructive/epidemiology/*etiology Risk Factors Smoking/adverse effects N1 - Mastrangelo, G Tartari, M Fedeli, U Fadda, E Saia, B eng Research Support, Non-U.S. Gov't England 2003/05/02 Occup Med (Lond). 2003 May;53(3):165-72. doi: 10.1093/occmed/kqg041. PY - 2003 SN - 0962-7480 (Print) 0962-7480 (Linking) SP - 165-72 ST - Ascertaining the risk of chronic obstructive pulmonary disease in relation to occupation using a case-control design T2 - Occup Med (Lond) TI - Ascertaining the risk of chronic obstructive pulmonary disease in relation to occupation using a case-control design UR - https://www.ncbi.nlm.nih.gov/pubmed/12724550 VL - 53 ID - 73 ER - TY - JOUR AB - BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality. Although the main risk factor is smoking, 15-19% of COPD even in smokers has been attributed to occupational exposures. The aim of this study was to investigate the association between occupational exposure and risk of COPD. METHODS: Participants were part of a cross sectional study of risk factors for COPD. A total of 1232 completed a detailed respiratory questionnaire, spirometric testing and measurement of gas transfer. Job histories were coded according to the International Standard Classification of Occupations. These codes were then used to establish occupational exposures using the ALOHA job exposure matrix. RESULTS: The prevalence of emphysema was 2.4%, chronic obstructive bronchitis 1.8%, and COPD 3.4%. Subjects ever exposed to biological dusts had an increased risk of chronic obstructive bronchitis (OR 3.19; 95% CI 1.27 to 7.97), emphysema (OR 3.18; 95% CI 1.41 to 7.13), and COPD (OR 2.70, 95% CI 1.39 to 5.23). These risks were higher in women than in men. For biological dust, the risk of emphysema and COPD was also significantly increased in both the duration of exposure categories, again in women but not in men. No significant increased risks for COPD were found for mineral dust (OR 1.13; 95% CI 0.57 to 2.27) or gases/fumes (OR 1.63; 95% CI 0.83 to 3.22). CONCLUSION: In this general population sample of adults, occupational exposures to biological dusts were associated with an increased risk of COPD which was higher in women. Preventive strategies should be aimed at reducing exposure to these agents in the workplace. AD - Department of Epidemiology and Preventive Medicine, Monash University, Central and Eastern Clinical School, The Alfred Hospital, Commercial Road, Melbourne 3004, Victoria, Australia. Melanie.Matheson@med.monash.edu.au AN - 16061705 AU - Matheson, M. C. AU - Benke, G. AU - Raven, J. AU - Sim, M. R. AU - Kromhout, H. AU - Vermeulen, R. AU - Johns, D. P. AU - Walters, E. H. AU - Abramson, M. J. C1 - 408 C2 - PMC1747486 DA - Aug DB - Medline DO - 10.1136/thx.2004.035170 DP - NLM IS - 8 KW - Aged *Dust Female Forced Expiratory Volume/physiology Humans Male Middle Aged Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*etiology/physiopathology Risk Factors Sex Distribution Smoking/adverse effects/physiopathology Vital Capacity/physiology N1 - Matheson, M C Benke, G Raven, J Sim, M R Kromhout, H Vermeulen, R Johns, D P Walters, E H Abramson, M J eng Research Support, Non-U.S. Gov't England 2005/08/03 Thorax. 2005 Aug;60(8):645-51. doi: 10.1136/thx.2004.035170. PY - 2005 SN - 0040-6376 (Print) 1468-3296 (Electronic) 0040-6376 (Linking) SP - 645-51 ST - Biological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary disease T2 - Thorax TI - Biological dust exposure in the workplace is a risk factor for chronic obstructive pulmonary disease UR - https://www.ncbi.nlm.nih.gov/pubmed/16061705 VL - 60 ID - 74 ER - TY - JOUR AB - This study investigated whether chronic airflow limitation and rapid decline in pulmonary function were associated with peak exposures to ozone and other irritant gases in pulp mills. Bleachery workers potentially exposed to irritant gassings (n = 178) from three Swedish pulp mills, and a comparison group of workers not exposed to irritant gassings (n = 54) from two paper mills, were studied. Baseline surveys occurred in 1995-1996, with follow-up surveys in 1998-1999. Participants performed spirometry and answered questions regarding ozone, chlorine dioxide (ClO2), and sulphur dioxide (SO2) gassings. From regression models controlling for potential confounders, declines in both the forced expiratory volume in one second (FEV1) (-24 mL x yr(-1)) and the forced vital capacity (FVC) (-19 mL x yr(-1)) were associated with ClO2/SO2 gassings. At follow-up, the prevalence of chronic airflow limitation (i.e. FEV1/FVC less than the lower limit of normal) was elevated for participants with only pre-baseline ozone gassings and with both pre-baseline and interval ozone gassings, after controlling for potential confounders. These findings suggest that obstructive effects among bleachery workers are associated with ozone gassings, and that adverse effects on spirometry might also accompany chlorine dioxide/sulphur dioxide gassings. Peak exposures to irritant gases in pulp mills should be prevented. AD - Division of Respiratory Disease Studies, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505, USA. AN - 15994400 AU - Mehta, A. J. AU - Henneberger, P. K. AU - Toren, K. AU - Olin, A. C. C1 - 411 C2 - Mehta 2005 DA - Jul DB - Medline DO - 10.1183/09031936.05.00083604 DP - NLM IS - 1 KW - Adult Air Pollutants, Occupational/*adverse effects Airway Resistance Case-Control Studies Chlorine Compounds/adverse effects Cohort Studies Confidence Intervals Female Follow-Up Studies Humans *Industry Lung Diseases/*chemically induced/epidemiology Male Middle Aged Occupational Diseases/diagnosis/epidemiology/*etiology Occupational Exposure/adverse effects Oxides/adverse effects Ozone/adverse effects Paper Probability Reference Values Regression Analysis Respiratory Function Tests Risk Assessment Spirometry/methods Sulfur Dioxide/adverse effects Sweden/epidemiology N1 - Mehta, A J Henneberger, P K Toren, K Olin, A-C eng Comparative Study Research Support, Non-U.S. Gov't England 2005/07/05 Eur Respir J. 2005 Jul;26(1):133-9. doi: 10.1183/09031936.05.00083604. PY - 2005 SN - 0903-1936 (Print) 0903-1936 (Linking) SP - 133-9 ST - Airflow limitation and changes in pulmonary function among bleachery workers T2 - Eur Respir J TI - Airflow limitation and changes in pulmonary function among bleachery workers UR - https://www.ncbi.nlm.nih.gov/pubmed/15994400 VL - 26 ID - 190 ER - TY - JOUR AB - RATIONALE: There is limited evidence from population-based studies demonstrating incidence of spirometric-defined chronic obstructive pulmonary disease (COPD) in association with occupational exposures. OBJECTIVES: We evaluated the association between occupational exposures and incidence of COPD in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA). MEASUREMENTS AND MAIN RESULTS: Prebronchodilator ratio of forced expiratory volume in 1 second over forced vital capacity (FEV(1)/FVC) was measured in 4,267 nonasthmatic SAPALDIA participants ages 18-62 at baseline in 1991 and at follow-up in 2001-2003. COPD was defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion (FEV(1)/FVC < 0.70) and Quanjer reference equation (FEV(1)/FVC < lower limit of normal [LLN]), and categorized by severity (>/= 80% and <80% predicted FEV(1) for stage I and stage II+, respectively). Using a job-exposure matrix, self-reported occupations at baseline were assigned exposures to biological dusts, mineral dusts, gases/fumes, and vapors, gases, dusts, or fumes (VGDF) (high, low, or unexposed as reference). Adjusted incident rate ratios (IRRs) of stage I and stage II+ COPD were estimated in mixed Poisson regression models. Statistically significant (P < 0.05) IRRs of stage II+ GOLD and LLN-COPD, indicating risks between two- and fivefold, were observed for all occupational exposures at high levels. Occupational exposure-associated risk of stage II+ COPD was observed mainly in males and ages >/= 40 years, and remained elevated when restricted to nonsmokers. CONCLUSIONS: In a Swiss working adult population, occupational exposures to biological dusts, mineral dusts, gases/fumes, and VGDF were associated with incidence of COPD of at least moderate severity. AD - Swiss Tropical and Public Health Institute, Basel, Switzerland. amehta@hsph.harvard.edu AN - 22492989 AU - Mehta, A. J. AU - Miedinger, D. AU - Keidel, D. AU - Bettschart, R. AU - Bircher, A. AU - Bridevaux, P. O. AU - Curjuric, I. AU - Kromhout, H. AU - Rochat, T. AU - Rothe, T. AU - Russi, E. W. AU - Schikowski, T. AU - Schindler, C. AU - Schwartz, J. AU - Turk, A. AU - Vermeulen, R. AU - Probst-Hensch, N. AU - Kunzli, N. AU - Team, Sapaldia C1 - 8505 C2 - Mehta 2012 DA - Jun 15 DB - Medline DO - 10.1164/rccm.201110-1917OC DP - NLM ET - 20120406 IS - 12 KW - Adolescent Adult Age Distribution Causality Cohort Studies Dust *Environmental Monitoring/methods Epidemiological Monitoring Female Gases/adverse effects Humans Incidence Male Middle Aged Occupational Diseases/*epidemiology/etiology/physiopathology Occupational Exposure/adverse effects/*statistics & numerical data Poisson Distribution Prognosis Prospective Studies Pulmonary Disease, Chronic Obstructive/*chemically induced/*epidemiology/physiopathology Severity of Illness Index Sex Distribution Spirometry Switzerland/epidemiology Young Adult N1 - Mehta, Amar J Miedinger, David Keidel, Dirk Bettschart, Robert Bircher, Andreas Bridevaux, Pierre-Olivier Curjuric, Ivan Kromhout, Hans Rochat, Thierry Rothe, Thomas Russi, Erich W Schikowski, Tamara Schindler, Christian Schwartz, Joel Turk, Alexander Vermeulen, Roel Probst-Hensch, Nicole Kunzli, Nino eng Comparative Study Multicenter Study Research Support, Non-U.S. Gov't 2012/04/12 Am J Respir Crit Care Med. 2012 Jun 15;185(12):1292-300. doi: 10.1164/rccm.201110-1917OC. Epub 2012 Apr 6. PY - 2012 SN - 1535-4970 (Electronic) 1073-449X (Linking) SP - 1292-300 ST - Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults T2 - Am J Respir Crit Care Med TI - Occupational exposure to dusts, gases, and fumes and incidence of chronic obstructive pulmonary disease in the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults UR - https://www.ncbi.nlm.nih.gov/pubmed/22492989 VL - 185 ID - 86 ER - TY - JOUR AB - OBJECTIVES: The present study sought to examine the long-term effects of exposure to respirable quartz on pulmonary function with particular focus on chronic obstructive pulmonary disease (COPD). METHODS: The study is based on the Wismut cohort of former uranium miners. Spirometric data were ascertained together with quantitative estimates of cumulative exposure to respirable quartz for each of 1421 study subjects born between 1954 and 1956. The case definition for COPD is based on the criteria of the Global Initiative for Chronic Obstructive Lung Disease. Linear mixed regression models were fitted to identify significant determinants of longitudinal changes in lung function parameters. RESULTS: An average of five spirometries were available for each miner. It was shown that cumulative exposure to 1 mg/m(3)-year respirable quartz leads, on average, to a relative reduction in forced expiratory volume in 1 s/ orced vital capacity (FEV(1)/FVC) of 2.75% (p<0.001). A nested case-control approach demonstrated that the risk for COPD stage I increases with increasing cumulative exposure to respirable quartz (OR 1.81 per 1 mg/m(3)-year). CONCLUSIONS: This paper adds further evidence on the long-term effects of exposure to respirable quartz, which include a decline in pulmonary function parameters and an increase in the incidence of COPD. AD - Department of Work and Health, Federal Institute for Occupational Safety and Health, Berlin, Germany. Moehner.Matthias@baua.bund.de AN - 23000825 AU - Mohner, M. AU - Kersten, N. AU - Gellissen, J. C1 - 416 C2 - Mohner 2013 DA - Jan DB - Medline DO - 10.1136/oemed-2012-100775 DP - NLM ET - 20120921 IS - 1 KW - Adolescent Adult Case-Control Studies Forced Expiratory Volume Humans Inhalation Exposure/adverse effects Longitudinal Studies Lung/*drug effects/physiopathology *Mining Occupational Diseases/*etiology/physiopathology Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*etiology/physiopathology Quartz/*adverse effects Risk Factors Spirometry Uranium Young Adult N1 - Mohner, Matthias Kersten, Norbert Gellissen, Johannes eng England 2012/09/25 Occup Environ Med. 2013 Jan;70(1):9-14. doi: 10.1136/oemed-2012-100775. Epub 2012 Sep 21. PY - 2013 SN - 1470-7926 (Electronic) 1351-0711 (Linking) SP - 9-14 ST - Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz T2 - Occup Environ Med TI - Chronic obstructive pulmonary disease and longitudinal changes in pulmonary function due to occupational exposure to respirable quartz UR - https://www.ncbi.nlm.nih.gov/pubmed/23000825 VL - 70 ID - 75 ER - TY - JOUR AB - Many insulating materials are used in construction, although few have been reported to cause non-malignant respiratory illnesses. We aimed to investigate associations between exposures to insulating materials and non-malignant respiratory illnesses in insulators. In this cross-sectional study, 990 insulators (45 +/- 14 years) were screened from 2011-2017 in Alberta. All participants underwent pulmonary function tests and chest radiography. Demographics, work history, and history of chest infections were obtained through questionnaires. Chronic obstructive pulmonary disease (COPD) was diagnosed according to established guidelines. Associations between exposures and respiratory illnesses were assessed by modified Poisson regression. Of those screened, 875 (88%) were males. 457 (46%) participants reported having >/= 1 chest infection in the past 3 years, while 156 (16%) were diagnosed with COPD. In multivariate models, all materials (asbestos, calcium silicate, carbon fibers, fiberglass, and refractory ceramic fibers) except aerogels and mineral fibers were associated with recurrent chest infections (prevalence ratio [PR] range: 1.18-1.42). Only asbestos was associated with COPD (PR: 1.44; 95% confidence interval [CI]: 1.01, 2.05). Therefore, occupational exposure to insulating materials was associated with non-malignant respiratory illnesses, specifically, recurrent chest infections and COPD. Longitudinal studies are urgently needed to assess the risk of exposure to these newly implemented insulation materials. AD - Alberta Respiratory Centre, Department of Medicine, University of Alberta, Edmonton, AB T6G 2R3, Canada. Synergy Respiratory & Cardiac Care, Sherwood Park, AB T8H 0N2, Canada. Department of Medicine, McMaster University & Firestone Institute for Respiratory Health, St. Joseph's Healthcare, Hamilton, ON L8N 4A6, Canada. AN - 32998195 AU - Moitra, S. AU - Farshchi Tabrizi, A. AU - Idrissi Machichi, K. AU - Kamravaei, S. AU - Miandashti, N. AU - Henderson, L. AU - Mukherjee, M. AU - Khadour, F. AU - Naseem, M. T. AU - Lacy, P. AU - Melenka, L. C1 - L.H. reports personal fees from Wellness of Workers (WoW) Program, Local 110 Heat & Frost Insulators & Allied Workers, and Synergy Respiratory Care Limited, during the conduct of the study. F.K., M.T.N., and L.M. report grants from Wellness of Workers (WoW) Program, Local 110 Heat & Frost Insulators & Allied Workers for the conduct of the study. M.M. reports personal fees from AstraZeneca Canada outside the submitted work. P.L. reports grants from Wellness of Workers (WoW) Program, Local 110 Heat & Frost Insulators & Allied Workers, and Synergy Respiratory Care Limited, during the conduct of the study; and personal fees from AstraZeneca Canada, outside the submitted work. Other authors do not have any conflict of interest to declare. C2 - PMC7579178 DA - Sep 28 DB - Medline DO - 10.3390/ijerph17197085 DP - NLM ET - 20200928 IS - 19 KW - Alberta/epidemiology Asbestos/analysis/*toxicity Asbestosis/*epidemiology Child Cross-Sectional Studies Humans Male Mineral Fibers/analysis Occupational Diseases/*epidemiology/etiology Occupational Exposure/adverse effects/*statistics & numerical data asbestos inhaled particles insulation materials occupational health pulmonary function tests N1 - Moitra, Subhabrata Farshchi Tabrizi, Ali Idrissi Machichi, Kawtar Kamravaei, Samineh Miandashti, Noushin Henderson, Linda Mukherjee, Manali Khadour, Fadi Naseem, Muhammad T Lacy, Paige Melenka, Lyle eng Research Support, Non-U.S. Gov't Switzerland 2020/10/02 Int J Environ Res Public Health. 2020 Sep 28;17(19):7085. doi: 10.3390/ijerph17197085. PY - 2020 SN - 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) ST - Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort T2 - Int J Environ Res Public Health TI - Non-Malignant Respiratory Illnesses in Association with Occupational Exposure to Asbestos and Other Insulating Materials: Findings from the Alberta Insulator Cohort UR - https://www.ncbi.nlm.nih.gov/pubmed/32998195 VL - 17 ID - 81 ER - TY - JOUR AB - BACKGROUND: In animal farming, respiratory disease has been associated with indoor air contaminants and an excess in FEV1 decline. Our aim was to determine the characteristics and risk factors for chronic obstructive pulmonary disease (COPD) in never-smoking European farmers working inside animal confinement buildings. METHODS: A sample of participants in the European Farmers' Study was selected for a cross-sectional study assessing lung function and air contaminants. Dose-response relationships were assessed using logistic regression models. RESULTS: COPD was found in 18 of 105 farmers (45.1 SD 11.7 years) (17.1%); 8 cases (7.6%) with moderate and 3 cases (2.9%) with severe disease. Dust and endotoxin showed a dose-response relationship with COPD, with the highest prevalence of COPD in subjects with high dust (low=7.9%/high=31.6%) and endotoxin exposure (low=10.5%/high=20.0%). This association was statistically significant for dust in the multivariate analysis (OR 6.60, 95% CI 1.10-39.54). CONCLUSION: COPD in never-smoking animal farmers working inside confinement buildings is related to indoor dust exposure and may become severe. AD - Servei de Pneumologia, Hospital Germans Trias i Pujol, Badalona, Catalonia, Spain. emonso@ns.hugtip.scs.es AN - 15376214 AU - Monso, E. AU - Riu, E. AU - Radon, K. AU - Magarolas, R. AU - Danuser, B. AU - Iversen, M. AU - Morera, J. AU - Nowak, D. C1 - 420 C2 - Monso 2004 DA - Oct DB - Medline DO - 10.1002/ajim.20077 DP - NLM IS - 4 KW - Adult Air Pollution, Indoor/*adverse effects/analysis Ammonia/analysis Animal Husbandry Animals Animals, Domestic Cross-Sectional Studies Dust/analysis Endotoxins/analysis Europe Female Humans Lung/physiopathology Male Middle Aged Occupational Exposure/*adverse effects Pulmonary Disease, Chronic Obstructive/*etiology Respiratory Function Tests Surveys and Questionnaires N1 - Monso, Eduard Riu, Elena Radon, Katja Magarolas, Ramon Danuser, Brigitta Iversen, Martin Morera, Josep Nowak, Dennis eng Research Support, Non-U.S. Gov't 2004/09/18 Am J Ind Med. 2004 Oct;46(4):357-62. doi: 10.1002/ajim.20077. PY - 2004 SN - 0271-3586 (Print) 0271-3586 (Linking) SP - 357-62 ST - Chronic obstructive pulmonary disease in never-smoking animal farmers working inside confinement buildings T2 - Am J Ind Med TI - Chronic obstructive pulmonary disease in never-smoking animal farmers working inside confinement buildings UR - https://www.ncbi.nlm.nih.gov/pubmed/15376214 VL - 46 ID - 108 ER - TY - JOUR AB - We investigated cumulative total cement dust exposure and ventilatory function impairment at a Portland cement factory in Tanzania. All 126 production workers were exposed. The control group comprised all 88 maintenance workers and 32 randomly chosen office workers. Exposed workers had significantly lower forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), peak expiratory flow rate (PEF), FEV1/FVC, FVC%, FEV1% and PEF%, than controls adjusted for age, duration of employment, height, and pack-years. Cumulative total dust exposure was significantly associated with reduced FVC, forced expiratory volume in 1 second, and peak expiratory flow rate adjusted for age, height and pack-years. Cumulative total dust exposure more than 300 mg/m year versus lower than 100 mg/m years was significantly associated with increased risk of developing airflow limitation (odds ratio = 9.9). The current occupational exposure limit for total cement dust (10 mg/m) appears to be too high to prevent respiratory health effects among cement workers. AD - Center for International Health, University of Bergen, Bergen, Norway. jmwaiselage@yahoo.com AN - 15247805 AU - Mwaiselage, J. AU - Bratveit, M. AU - Moen, B. AU - Mashalla, Y. C1 - 421 C2 - Mwaiselage 2004 DA - Jul DB - Medline DO - 10.1097/01.jom.0000131787.02250.79 DP - NLM IS - 7 KW - Adult Case-Control Studies *Construction Materials Cross-Sectional Studies *Dust Humans Lung Diseases/*etiology Male Middle Aged *Occupational Exposure Occupations Odds Ratio Respiratory Function Tests Risk Factors Tanzania N1 - Mwaiselage, Julius Bratveit, Magne Moen, Bente Mashalla, Yohana eng Research Support, Non-U.S. Gov't 2004/07/13 J Occup Environ Med. 2004 Jul;46(7):658-67. doi: 10.1097/01.jom.0000131787.02250.79. PY - 2004 SN - 1076-2752 (Print) 1076-2752 (Linking) SP - 658-67 ST - Cement dust exposure and ventilatory function impairment: an exposure-response study T2 - J Occup Environ Med TI - Cement dust exposure and ventilatory function impairment: an exposure-response study UR - https://www.ncbi.nlm.nih.gov/pubmed/15247805 VL - 46 ID - 76 ER - TY - JOUR AB - Cement dust exposure has previously been associated with airway symptoms and ventilatory impairment. The aim of the present study was to examine lung function and airway symptoms among employees in different jobs and at different levels of exposure to thoracic dust in the cement production industry. At the start of a 4-yr prospective cohort study in 2007, exposure to cement dust, symptoms and lung function were recorded cross-sectionally in 4,265 employees in 24 European cement plants. Bronchial exposure was assessed by 2,670 full-shift dust samples with cyclones collecting the thoracic aerosol fraction. A job exposure matrix was constructed by grouping dust concentrations according to job type and plant. Elevated odds ratios for symptoms and airflow limitation (range 1.2-2.6 in the highest quartile), but not for chronic bronchitis, were found in the higher quartiles of exposure compared with the lowest quartile. Forced expiratory volume in 1 s (FEV(1)) showed an exposure-response relationship with a 270-mL deficit of FEV(1) (95% CI 190-300 mL) in the highest compared with the lowest exposure level. The results support the hypothesis that exposure to dust in cement production may lead to respiratory symptoms and airway obstruction. AD - National Institute of Occupational Health, PO Box 8149 Dep, NO-0033 Oslo, Norway. kcn@stami.no AN - 21659410 AU - Nordby, K. C. AU - Fell, A. K. AU - Noto, H. AU - Eduard, W. AU - Skogstad, M. AU - Thomassen, Y. AU - Bergamaschi, A. AU - Kongerud, J. AU - Kjuus, H. C1 - 427 C2 - Nordby 2011 DA - Dec DB - Medline DO - 10.1183/09031936.00007711 DP - NLM ET - 20110609 IS - 6 KW - Adult Air Pollutants, Occupational/*toxicity Airway Obstruction/*etiology/physiopathology Bronchitis, Chronic/etiology/physiopathology Cohort Studies Construction Materials/*toxicity *Dust Europe/epidemiology Female Humans *Inhalation Exposure Lung/*physiopathology Male Middle Aged Occupational Diseases/*etiology/physiopathology *Occupational Exposure Prospective Studies Respiratory Function Tests Smoking/epidemiology Spirometry N1 - Nordby, K-C Fell, A K M Noto, H Eduard, W Skogstad, M Thomassen, Y Bergamaschi, A Kongerud, J Kjuus, H eng England 2011/06/11 Eur Respir J. 2011 Dec;38(6):1278-86. doi: 10.1183/09031936.00007711. Epub 2011 Jun 9. PY - 2011 SN - 1399-3003 (Electronic) 0903-1936 (Linking) SP - 1278-86 ST - Exposure to thoracic dust, airway symptoms and lung function in cement production workers T2 - Eur Respir J TI - Exposure to thoracic dust, airway symptoms and lung function in cement production workers UR - https://www.ncbi.nlm.nih.gov/pubmed/21659410 VL - 38 ID - 77 ER - TY - JOUR AB - OBJECTIVE: Farmers have an increased risk for chronic bronchitis and airflow obstruction. The objective of this study was to investigate the association of these health outcomes with farm activities. METHODS: We evaluated the Keokuk County Rural Health Study (KCRHS) enrollment data for farm activities and the two health outcomes chronic bronchitis based on self-reported symptoms and airflow obstruction based on spirometry. We used logistic regression to model the health outcomes, yielding an odds ratio (OR) and 95% confidence interval (95% CI) for farm activities while adjusting for potential confounders and other risk factors. RESULTS: Of the 1234 farmers, 104 (8.4%) had chronic bronchitis, 75 (6.1%) fulfilled the criteria for airflow obstruction, and the two outcomes overlapped by 18 participants. Chronic bronchitis without airflow obstruction (n = 86) had a statistically significant association with crop storage insecticides (OR 3.1, 95% CI 1.6, 6.1) and a low number of years (/= 18 years, spanning the duration from (2017-2018) until 2020. A meticulous matching process yielded a cohort of 708 COPD patients, each paired with a control subject, forming a harmonious 1:1 ratio. Multiple logistic regression analysis was employed to scrutinize the associations between smoking, dust exposure with COPD among coal workers. RESULTS: The COPD prevalence within the cohort of coal workers under investigation amounted to 22.66%, with an accompanying incidence density of 0.09/person-year. Following meticulous adjustment for confounding variables, it was discerned that cumulative dust exposure within the range of 47.19 ~ (OR: 1.90, 95% CI: 1.05, 3.44), 101.27 ~ (OR: 1.99, 95% CI: 1.17, 3.39), as well as smoking indices of 72 ~ (OR: 1.85, 95% CI: 1.19, 2.88), 145 ~ (OR: 1.74, 95% CI: 1.17, 2.61), 310 ~ (OR: 1.85, 95% CI: 1.23, 2.77) engender an escalated vulnerability to COPD among coal workers. Furthermore, interaction analysis discerned an absence of both multiplicative and additive interactions between dust exposure, smoking, and COPD occurrence amidst coal workers. CONCLUSION: Dust exposure and smoking were unequivocally identified as precipitating risk factors for COPD incidence within the population of coal workers, albeit devoid of any discernible interaction between these two causal agents. AD - School of Public Health, Caofeidian New Town, North China University of Science and Technology, No.21 Bohai Avenue, Tangshan City, Hebei Province, 063210, People's Republic of China. Personnel Department, North China University of Science and Technology, Tangshan City, Hebei Province, China. suyu@ncst.edu.cn. School of Public Health, North China University of Science and Technology, Tangshan, Hebei Province, China. wujianhui555@163.com. AN - 37864177 AU - Wang, H. AU - Meng, R. AU - Wang, X. AU - Si, Z. AU - Zhao, Z. AU - Lu, H. AU - Wang, H. AU - Hu, J. AU - Zheng, Y. AU - Chen, J. AU - Zhao, Z. AU - Zhu, H. AU - Li, X. AU - Xue, L. AU - Yan, S. AU - Sun, J. AU - Su, Y. AU - Wu, J. C1 - The authors declare that they have no competing interests. C2 - PMC10588135 DA - Oct 20 DB - Medline DO - 10.1186/s12889-023-16944-6 DP - NLM ET - 20231020 IS - 1 KW - Humans Case-Control Studies Coal/adverse effects *Occupational Exposure/adverse effects *Pulmonary Disease, Chronic Obstructive/epidemiology/etiology *Lung Diseases Smoking/adverse effects/epidemiology Dust/analysis *Coal Mining Copd Coal workers Dust exposure Interaction Smoking N1 - Wang, Hui Meng, Rui Wang, Xuelin Si, Zhikang Zhao, Zekun Lu, Haipeng Wang, Huan Hu, Jiaqi Zheng, Yizhan Chen, Jiaqi Zhao, Ziqi Zhu, Hongmin Li, Xiaoming Xue, Ling Yan, Shengguang Sun, Jian Su, Yu Wu, Jianhui eng Research Support, Non-U.S. Gov't England 2023/10/21 BMC Public Health. 2023 Oct 20;23(1):2056. doi: 10.1186/s12889-023-16944-6. PY - 2023 SN - 1471-2458 (Electronic) 1471-2458 (Linking) SP - 2056 ST - A nested case-control study of the effects of dust exposure, smoking on COPD in coal workers T2 - BMC Public Health TI - A nested case-control study of the effects of dust exposure, smoking on COPD in coal workers UR - https://www.ncbi.nlm.nih.gov/pubmed/37864177 VL - 23 ID - 91 ER - TY - JOUR AB - Coal workers are more likely to develop chronic obstructive pulmonary disease due to exposure to occupational hazards such as dust. In this study, a risk scoring system is constructed according to the optimal model to provide feasible suggestions for the prevention of chronic obstructive pulmonary disease in coal workers. Using 3955 coal workers who participated in occupational health check-ups at Gequan mine and Dongpang mine of Hebei Jizhong Energy from July 2018 to August 2018 as the study subjects, random forest, logistic regression, and convolutional neural network models are established, and model performance is evaluated to select the optimal model, and finally a risk scoring system is constructed according to the optimal model to achieve model visualization. The training set results show that the logistic, random forest, and CNN models have sensitivities of 78.55%, 86.89%, and 77.18%; specificities of 85.23%, 92.32%, and 87.61%; accuracies of 81.21%, 85.40%, and 83.02%; Brier scores of 0.14, 0.10, and 0.14; and AUCs of 0.76, 0.88, and 0.78, respectively, and similar results are obtained for the test set and validation set, with the random forest model outperforming the other two models. The risk scoring system constructed according to the importance ranking of random forest predictor variables has an AUC of 0.842; the evaluation results of the risk scoring system shows that its accuracy rate is 83.7% and the AUC is 0.827, and the established risk scoring system has good discriminatory ability. The random forest model outperforms the CNN and logistic regression models. The chronic obstructive pulmonary disease risk scoring system constructed based on the random forest model has good discriminatory power. AD - School of Public Health, North China University of Science and Technology, No. 21 Bohai Avenue, Caofeidian New Town, Tangshan 063210, China. AN - 36834351 AU - Wang, H. AU - Meng, R. AU - Wang, X. AU - Si, Z. AU - Zhao, Z. AU - Lu, H. AU - Wang, H. AU - Hu, J. AU - Zheng, Y. AU - Chen, J. AU - Zheng, Z. AU - Chen, Y. AU - Yang, Y. AU - Li, X. AU - Xue, L. AU - Sun, J. AU - Wu, J. C1 - The authors declare that they have no competing interest. C2 - PMC9960526 DA - Feb 18 DB - Medline DO - 10.3390/ijerph20043655 DP - NLM ET - 20230218 IS - 4 KW - Humans Coal *Coal Mining *Pulmonary Disease, Chronic Obstructive Dust Risk Assessment *Occupational Exposure chronic obstructive pulmonary disease coal workers random forest model risk assessment model risk scoring system N1 - Wang, Hui Meng, Rui Wang, Xuelin Si, Zhikang Zhao, Zekun Lu, Haipeng Wang, Huan Hu, Jiaqi Zheng, Yizhan Chen, Jiaqi Zheng, Ziwei Chen, Yuanyu Yang, Yongzhong Li, Xiaoming Xue, Ling Sun, Jian Wu, Jianhui eng Research Support, Non-U.S. Gov't Switzerland 2023/02/26 Int J Environ Res Public Health. 2023 Feb 18;20(4):3655. doi: 10.3390/ijerph20043655. PY - 2023 SN - 1660-4601 (Electronic) 1661-7827 (Print) 1660-4601 (Linking) ST - Development and Internal Validation of Risk Assessment Models for Chronic Obstructive Pulmonary Disease in Coal Workers T2 - Int J Environ Res Public Health TI - Development and Internal Validation of Risk Assessment Models for Chronic Obstructive Pulmonary Disease in Coal Workers UR - https://www.ncbi.nlm.nih.gov/pubmed/36834351 VL - 20 ID - 90 ER - TY - JOUR AB - INTRODUCTION: Although several studies have studied the relationship between occupational exposure to crystalline silica dust and respiratory mortality, few have examined the relationship with impairments in respiratory function and the exposure threshold triggering spirometric monitoring in exposed workers. The objective of the present study was to evaluate the impact of exposure to crystalline silica dust on respiratory function. METHODS: We included 1428 male participants (aged 40 to 65) recruited from the French general population, at random from electoral rolls, in the cross-sectional ELISABET study and for whom data on forced expiratory flow-volume curve indices z-scores (calculated using the Global Lung Function Initiative 2012 equations) and exposure (via a questionnaire) were available. A cumulative exposure index (CEI) for crystalline silica dust (CEI(silica), expressed in mg.m(-3).year) was calculated using the Matgene occupational exposure matrix. RESULTS: 293 of the 1428 participants (20.52%) reported exposure to silica dust. We found that the adjusted z-scores for the forced expiratory volume in the first second/forced vital capacity (FEV(1)/FVC) ratio decreased significantly as CEI(silica) increased. After adjustment, the adjusted z-scores for FEV(1)/FVC (beta: -0.426 (95% confidence interval (CI): -0.792, -0.060) per 1 mg m(-3).year increment) and the mean forced expiratory flow between 25 and 75% of the forced vital capacity (FEF(25-75)) (beta: -0.552 (95% CI: -0.947, -0.157)) were significantly lower in the participants with CEI(silica) >/=1 mg m(-3).year than in non-exposed participants. The likelihoods of having airway obstruction (odds ratio (OR): 3.056 (95% CI: 1.107, 7.626)) or having an impaired FEF(25-75) (OR: 4.305 (95% CI: 1.393, 11.79)) were also significantly higher in participants with CEI(silica) >/=1 mg m(-3).year. CONCLUSION: Our results emphasize the importance of spirometry-based monitoring in workers exposed to more than 1 mg m(-3).year of crystalline silica dust, in order to identify small airway obstruction or airway obstruction as early as possible. AD - Univ. Lille, CHU Lille, Institut Pasteur Lille, ULR 4483 - IMPECS - IMPact de l'Environnement Chimique sur la Sante humaine, F-59000, Lille, France. Electronic address: pierre-marie.wardyn@univ-lille.fr. Univ. Lille, ULR 4483 - IMPECS - IMPact de l'Environnement Chimique sur la, Sante humaine, F-59000, Lille, France. Univ. Lille, CHU Lille, Institut Pasteur Lille, ULR 4483 - IMPECS - IMPact de l'Environnement Chimique sur la Sante humaine, F-59000, Lille, France. Univ. Lille, INSERM, CHU Lille, Institut Pasteur de Lille, U1167-RID-AGE-Facteurs de risque et determinants moleculaires des maladies liees au vieillissement, Lille, F-59000, France. AN - 36736759 AU - Wardyn, P. M. AU - Edme, J. L. AU - de Broucker, V. AU - Cherot-Kornobis, N. AU - Ringeval, D. AU - Amouyel, P. AU - Sobaszek, A. AU - Dauchet, L. AU - Hulo, S. C1 - Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. C2 - Wardyn 2023 DA - Apr 1 DB - Medline DO - 10.1016/j.envres.2023.115382 DP - NLM ET - 20230201 KW - Humans Male Cross-Sectional Studies Dust *Airway Obstruction *Occupational Exposure/analysis Vital Capacity Forced Expiratory Volume Silicon Dioxide Lung Airway obstruction Crystalline silica dust Fef(25-75) Gli-2012 Occupational exposure Spirometry N1 - Wardyn, Pierre-Marie Edme, Jean-Louis de Broucker, Virginie Cherot-Kornobis, Nathalie Ringeval, David Amouyel, Philippe Sobaszek, Annie Dauchet, Luc Hulo, Sebastien eng Netherlands 2023/02/04 Environ Res. 2023 Apr 1;222:115382. doi: 10.1016/j.envres.2023.115382. Epub 2023 Feb 1. PY - 2023 SN - 1096-0953 (Electronic) 0013-9351 (Linking) SP - 115382 ST - The impact of occupational exposure to crystalline silica dust on respiratory function (airway obstruction and FEF(25-75)) in the French general population T2 - Environ Res TI - The impact of occupational exposure to crystalline silica dust on respiratory function (airway obstruction and FEF(25-75)) in the French general population UR - https://www.ncbi.nlm.nih.gov/pubmed/36736759 VL - 222 ID - 65 ER - TY - JOUR AB - OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTSOccupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD. AD - Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon 97227, USA. sheila.weinmann@kpchr.org AN - 18469625 AU - Weinmann, S. AU - Vollmer, W. M. AU - Breen, V. AU - Heumann, M. AU - Hnizdo, E. AU - Villnave, J. AU - Doney, B. AU - Graziani, M. AU - McBurnie, M. A. AU - Buist, A. S. C1 - 204 C2 - Weinmann 2008 DA - May DB - Medline DO - 10.1097/JOM.0b013e3181651556 DP - NLM IS - 5 KW - Aged Air Pollutants, Occupational/*adverse effects/analysis Algorithms Case-Control Studies Dust/analysis Female Health Maintenance Organizations Humans Interviews as Topic Logistic Models Male Middle Aged Occupational Exposure/*adverse effects/analysis/prevention & control Oregon/epidemiology Pulmonary Disease, Chronic Obstructive/*chemically induced/*epidemiology/prevention & control Respiratory Protective Devices Smoking/epidemiology Spirometry N1 - Weinmann, Sheila Vollmer, William M Breen, Victor Heumann, Michael Hnizdo, Eva Villnave, Jacqueline Doney, Brent Graziani, Monica McBurnie, Mary Ann Buist, A Sonia eng MM-0247-03/03/PHS HHS/ Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. 2008/05/13 J Occup Environ Med. 2008 May;50(5):561-9. doi: 10.1097/JOM.0b013e3181651556. PY - 2008 SN - 1536-5948 (Electronic) 1076-2752 (Linking) SP - 561-9 ST - COPD and occupational exposures: a case-control study T2 - J Occup Environ Med TI - COPD and occupational exposures: a case-control study UR - https://www.ncbi.nlm.nih.gov/pubmed/18469625 VL - 50 ID - 64 ER - TY - JOUR AB - The aim was to explore the impact of occupation on chronic obstructive pulmonary disease (COPD) in a cross-sectional population-based study among subjects aged 45 to 84 years. In a stratified sampling 89 general practitioners practices (GPP) in Denmark recruited 3106 males and 1636 females through the Danish Civil Registration System. COPD was defined by spirometry by the 2.5(th)-centile Lower Limit of Normal of FEV1 and FEV1/FVC. Information about smoking, occupational exposure and the respective occupations were obtained from questionnaires. Occupations followed the Danish adaptation of The International Standard Classification of Occupations, revision 1988 (DISCO-88). Exposure to vapour, gas, dust (organic and inorganic), and fume (VGDF) in each occupation (yes/no) was evaluated by two independent specialist in occupational medicine. Exposures were divided in no, low, medium, and high exposure as 0, < 5, 5-14, and >/= 15 years in the job, respectively. Data was analysed by a mixed random effect logistic regression model. The age-standardised COPD study prevalence was 5.0%. Of 372 DISCO-88 codes 72 were identified with relevant exposure to VGDF. 46% of the participants reported at least one occupation with VGDF exposure. Adjusted for smoking, age, sex, and GPP a dose-dependent association of COPD was found among workers in jobs with high organic dust exposure, with OR 1.56 (95% CI 1.09-2.24). Restricted to agriculture the OR was 1.59 (95% CI: 1.08-2.33). No association was observed for workers in jobs with inorganic dust, fume/gas, or vapour exposures. In summary, occupational organic dust exposure was associated to the prevalence of COPD. AD - a Department of Occupational Medicine, Danish Ramazzini Centre , Aalborg University Hospital , Aalborg , Denmark. AN - 25415831 AU - Wurtz, E. T. AU - Schlunssen, V. AU - Malling, T. H. AU - Hansen, J. G. AU - Omland, O. C1 - 207b C2 - Wurtz 2015 DA - Aug DB - Medline DO - 10.3109/15412555.2014.974739 DP - NLM IS - 4 KW - Aged Aged, 80 and over Air Pollutants, Occupational/*toxicity Cross-Sectional Studies Denmark/epidemiology Female Humans Logistic Models Male Middle Aged Occupational Diseases/diagnosis/epidemiology/*etiology Occupational Exposure/*adverse effects/statistics & numerical data Prevalence Pulmonary Disease, Chronic Obstructive/diagnosis/epidemiology/*etiology Risk Factors Spirometry epidemiology occupational exposure organic dust prevalence study N1 - Wurtz, Else Toft Schlunssen, Vivi Malling, Tine Halsen Hansen, Jens Georg Omland, Oyvind eng England 2014/11/22 COPD. 2015 Aug;12(4):435-43. doi: 10.3109/15412555.2014.974739. PY - 2015 SN - 1541-2563 (Electronic) 1541-2563 (Linking) SP - 435-43 ST - Occupational Chronic Obstructive Pulmonary Disease in a Danish Population-Based Study T2 - COPD TI - Occupational Chronic Obstructive Pulmonary Disease in a Danish Population-Based Study UR - https://www.ncbi.nlm.nih.gov/pubmed/25415831 VL - 12 ID - 99 ER -